Equine Protozoal Myeloencephalitis: An Updated Consensus Statement with a Focus on Parasite Biology, Diagnosis, Treatment, and Prevention

S. M. Reed, M. Furr, D. K. Howe, A. L. Johnson, R. J. Mackay, J. K. Morrow, Nicola Pusterla, S. Witonsky

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Equine protozoal myeloencephalitis (EPM) remains an important neurologic disease of horses. There are no pathognomonic clinical signs for the disease. Affected horses can have focal or multifocal central nervous system (CNS) disease. EPM can be difficult to diagnose antemortem. It is caused by either of 2 parasites, Sarcocystis neurona and Neospora hughesi, with much less known about N. hughesi. Although risk factors such as transport stress and breed and age correlations have been identified, biologic factors such as genetic predispositions of individual animals, and parasite-specific factors such as strain differences in virulence, remain largely undetermined. This consensus statement update presents current published knowledge of the parasite biology, host immune response, disease pathogenesis, epidemiology, and risk factors. Importantly, the statement provides recommendations for EPM diagnosis, treatment, and prevention.

Original languageEnglish (US)
Pages (from-to)491-502
Number of pages12
JournalJournal of Veterinary Internal Medicine
Volume30
Issue number2
DOIs
StatePublished - Mar 1 2016

Fingerprint

equine protozoal myeloencephalitis
Encephalomyelitis
Neospora hughesi
Horses
Parasites
parasites
Biological Sciences
risk factors
Sarcocystis neurona
horses
central nervous system diseases
nervous system diseases
strain differences
epidemiology
Sarcocystis
Neospora
virulence
pathogenesis
immune response
Central Nervous System Diseases

Keywords

  • Encephalitis
  • Equine myeloencephalopathy
  • Equine neurologic
  • Equine protozoal disease
  • Myelitis
  • Neospora hughesi
  • Sarcocystis neurona

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Equine Protozoal Myeloencephalitis : An Updated Consensus Statement with a Focus on Parasite Biology, Diagnosis, Treatment, and Prevention. / Reed, S. M.; Furr, M.; Howe, D. K.; Johnson, A. L.; Mackay, R. J.; Morrow, J. K.; Pusterla, Nicola; Witonsky, S.

In: Journal of Veterinary Internal Medicine, Vol. 30, No. 2, 01.03.2016, p. 491-502.

Research output: Contribution to journalReview article

Reed, S. M. ; Furr, M. ; Howe, D. K. ; Johnson, A. L. ; Mackay, R. J. ; Morrow, J. K. ; Pusterla, Nicola ; Witonsky, S. / Equine Protozoal Myeloencephalitis : An Updated Consensus Statement with a Focus on Parasite Biology, Diagnosis, Treatment, and Prevention. In: Journal of Veterinary Internal Medicine. 2016 ; Vol. 30, No. 2. pp. 491-502.
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