Equine herpesvirus 1 infection of horses

studies on the experimentally induced neurologic disease.

T. A. Jackson, Bennie Osburn, D. R. Cordy, J. W. Kendrick

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Experimental infection with equine herpesvirus 1 (rhinopneumonitis) resulted in neurologic disease in 8 of 15 inoculated horses. Nonpregnant animals did not develop clinical disease, and microscopic examination of tissues revealed no changes. In all mares between 3 and 9 months of gestation, a neurologic syndrome appeared 6 to 8 days after inoculation. Mares inoculated when 10 months pregnant did not develop neurologic disorders, but several aborted. The histopathologic change common to both sequelae was vasculitis, involving smaller arteries and veins. Although blood vessel changes were detected in endometrium of all pregnant mares, vascular changes were present in the central nervous system only in mares having neurologic disease. Concomitant degeneration of nervous tissue occurred within the central nervous system and, in many sites, anatomic and temporal relationships of vasculitis and nervous tissue degeneration suggested a cause-effect relationship. This theory was strengthened by the lack of usual histopathologic indications of encephalomyelitis. In cerebrospinal fluid from affected mares, there was an increase in protein but not pleocytosis.

Original languageEnglish (US)
Pages (from-to)709-719
Number of pages11
JournalAmerican Journal of Veterinary Research
Volume38
Issue number6
StatePublished - Jun 1 1977
Externally publishedYes

Fingerprint

Equid Herpesvirus 1
Equid herpesvirus 1
Herpesviridae Infections
nervous system diseases
Nervous System Diseases
mares
Horses
Nerve Tissue
Vasculitis
horses
Blood Vessels
Central Nervous System
vasculitis
infection
Encephalomyelitis
blood vessels
Leukocytosis
central nervous system
Endometrium
Nervous System

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Equine herpesvirus 1 infection of horses : studies on the experimentally induced neurologic disease. / Jackson, T. A.; Osburn, Bennie; Cordy, D. R.; Kendrick, J. W.

In: American Journal of Veterinary Research, Vol. 38, No. 6, 01.06.1977, p. 709-719.

Research output: Contribution to journalArticle

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