Abstract
Equine herpesvirus (EHV)-1 and -4 associated respiratory disease in the horse occurs worldwide. Clinically there are no distinguishing characteristics between EHV-1 and EHV-4 infection. Disease is spread between animals by aerosolized virus, direct contact with infected respiratory secretions, or fomites. Diagnosis can be made by virus isolation, PCR of nasopharyngeal secretions or peripheral blood mononuclear cells, or serology. The characteristics of the protective immune response against EHV-1/4 infection have not been well described, but it is likely a combination of humoral and cell-mediated immunity. Current vaccines stimulate primarily a humoral immune response, which may decrease the severity of clinical signs, viremia, and viral shedding, but does not provide protection from infection. Since suckling foals have recently been shown to be an important reservoir in the transmission of EHV-1 and EHV-4, they ought to be the target for immunoprophylaxis to eliminate or significantly reduce EHV infections in the field and prevent the establishment of a latent state. Until more effective vaccine strategies are developed, appropriate herd management is essential to preventing or containing outbreaks of EHV-1/4.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-202 |
| Number of pages | 6 |
| Journal | Clinical Techniques in Equine Practice |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2006 |
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Keywords
- EHV-1
- EHV-4
- equine
- respiratory disease
ASJC Scopus subject areas
- Equine
Cite this
Equine Herpesvirus 1 and 4 Respiratory Disease in the Horse. / Harless, Wendy; Pusterla, Nicola.
In: Clinical Techniques in Equine Practice, Vol. 5, No. 3, 09.2006, p. 197-202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Equine Herpesvirus 1 and 4 Respiratory Disease in the Horse
AU - Harless, Wendy
AU - Pusterla, Nicola
PY - 2006/9
Y1 - 2006/9
N2 - Equine herpesvirus (EHV)-1 and -4 associated respiratory disease in the horse occurs worldwide. Clinically there are no distinguishing characteristics between EHV-1 and EHV-4 infection. Disease is spread between animals by aerosolized virus, direct contact with infected respiratory secretions, or fomites. Diagnosis can be made by virus isolation, PCR of nasopharyngeal secretions or peripheral blood mononuclear cells, or serology. The characteristics of the protective immune response against EHV-1/4 infection have not been well described, but it is likely a combination of humoral and cell-mediated immunity. Current vaccines stimulate primarily a humoral immune response, which may decrease the severity of clinical signs, viremia, and viral shedding, but does not provide protection from infection. Since suckling foals have recently been shown to be an important reservoir in the transmission of EHV-1 and EHV-4, they ought to be the target for immunoprophylaxis to eliminate or significantly reduce EHV infections in the field and prevent the establishment of a latent state. Until more effective vaccine strategies are developed, appropriate herd management is essential to preventing or containing outbreaks of EHV-1/4.
AB - Equine herpesvirus (EHV)-1 and -4 associated respiratory disease in the horse occurs worldwide. Clinically there are no distinguishing characteristics between EHV-1 and EHV-4 infection. Disease is spread between animals by aerosolized virus, direct contact with infected respiratory secretions, or fomites. Diagnosis can be made by virus isolation, PCR of nasopharyngeal secretions or peripheral blood mononuclear cells, or serology. The characteristics of the protective immune response against EHV-1/4 infection have not been well described, but it is likely a combination of humoral and cell-mediated immunity. Current vaccines stimulate primarily a humoral immune response, which may decrease the severity of clinical signs, viremia, and viral shedding, but does not provide protection from infection. Since suckling foals have recently been shown to be an important reservoir in the transmission of EHV-1 and EHV-4, they ought to be the target for immunoprophylaxis to eliminate or significantly reduce EHV infections in the field and prevent the establishment of a latent state. Until more effective vaccine strategies are developed, appropriate herd management is essential to preventing or containing outbreaks of EHV-1/4.
KW - EHV-1
KW - EHV-4
KW - equine
KW - respiratory disease
UR - http://www.scopus.com/inward/record.url?scp=33747351337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747351337&partnerID=8YFLogxK
U2 - 10.1053/j.ctep.2006.03.014
DO - 10.1053/j.ctep.2006.03.014
M3 - Article
AN - SCOPUS:33747351337
VL - 5
SP - 197
EP - 202
JO - Clinical Techniques in Equine Practice
JF - Clinical Techniques in Equine Practice
SN - 1534-7516
IS - 3
ER -