Abstract
Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 93-122 |
| Number of pages | 30 |
| Journal | Veterinary Microbiology |
| Volume | 167 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 29 2013 |
Fingerprint
Keywords
- EAV
- Equine arteritis virus
- EVA
ASJC Scopus subject areas
- Microbiology
- veterinary(all)
Cite this
Equine arteritis virus. / Balasuriya, Udeni B R; Go, Yun Young; Maclachlan, Nigel J.
In: Veterinary Microbiology, Vol. 167, No. 1-2, 29.11.2013, p. 93-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Equine arteritis virus
AU - Balasuriya, Udeni B R
AU - Go, Yun Young
AU - Maclachlan, Nigel J
PY - 2013/11/29
Y1 - 2013/11/29
N2 - Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies.
AB - Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies.
KW - EAV
KW - Equine arteritis virus
KW - EVA
UR - http://www.scopus.com/inward/record.url?scp=84889089738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84889089738&partnerID=8YFLogxK
U2 - 10.1016/j.vetmic.2013.06.015
DO - 10.1016/j.vetmic.2013.06.015
M3 - Article
C2 - 23891306
AN - SCOPUS:84889089738
VL - 167
SP - 93
EP - 122
JO - Veterinary Microbiology
JF - Veterinary Microbiology
SN - 0378-1135
IS - 1-2
ER -