Epoxide hydrolases: Their roles and interactions with lipid metabolism

John W. Newman, Christophe Morisseau, Bruce D. Hammock

Research output: Contribution to journalArticle

289 Citations (Scopus)

Abstract

The epoxide hydrolases (EHs) are enzymes present in all living organisms, which transform epoxide containing lipids by the addition of water. In plants and animals, many of these lipid substrates have potent biologically activities, such as host defenses, control of development, regulation of inflammation and blood pressure. Thus the EHs have important and diverse biological roles with profound effects on the physiological state of the host organisms. Currently, seven distinct epoxide hydrolase sub-types are recognized in higher organisms. These include the plant soluble EHs, the mammalian soluble epoxide hydrolase, the hepoxilin hydrolase, leukotriene A4 hydrolase, the microsomal epoxide hydrolase, and the insect juvenile hormone epoxide hydrolase. While our understanding of these enzymes has progressed at different rates, here we discuss the current state of knowledge for each of these enzymes, along with a distillation of our current understanding of their endogenous roles. By reviewing the entire enzyme class together, both commonalities and discrepancies in our understanding are highlighted and important directions for future research pertaining to these enzymes are indicated.

Original languageEnglish (US)
Pages (from-to)1-51
Number of pages51
JournalProgress in Lipid Research
Volume44
Issue number1
DOIs
StatePublished - Jan 2005

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Epoxide Hydrolases
Lipid Metabolism
Enzymes
Insect Hormones
Lipids
Hydrolases
Distillation
Epoxy Compounds
Blood pressure
Animals
Blood Pressure
Inflammation
Water
Substrates

ASJC Scopus subject areas

  • Cell Biology

Cite this

Epoxide hydrolases : Their roles and interactions with lipid metabolism. / Newman, John W.; Morisseau, Christophe; Hammock, Bruce D.

In: Progress in Lipid Research, Vol. 44, No. 1, 01.2005, p. 1-51.

Research output: Contribution to journalArticle

Newman, John W. ; Morisseau, Christophe ; Hammock, Bruce D. / Epoxide hydrolases : Their roles and interactions with lipid metabolism. In: Progress in Lipid Research. 2005 ; Vol. 44, No. 1. pp. 1-51.
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