Epizootic coronaviral typhlocolitis in suckling mice

Stephen W Barthold, A. L. Smith, P. F S Lord, P. N. Bhatt, R. O. Jacoby, A. J. Main

Research output: Chapter in Book/Report/Conference proceedingChapter

36 Citations (Scopus)

Abstract

Multiple epizootics of typhlocolitis associated with high morbidity and mortality occurred among suckling mice in an arbovirology research laboratory. Affected mice had necrosis and hyperplasia of cecal, colonic, and less often, small intestinal mucosa. Epithelial syncytia were present throughout the affected areas. Other organs generally were not involved. The etiologic agent was a coronavirus antigenically related to mouse hepatitis virus strains 1 and S. Sera from dams of affected litters and recovered animals did not contain detectable complement fixing antibody to coronavirus antigen. The lesions and the causative agent differed from previously reported coronaviral syndromes in mice. The source of the infection was not definitely found.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
Pages376-383
Number of pages8
Volume32
Edition4
StatePublished - 1982
Externally publishedYes

Fingerprint

Coronavirus
Murine hepatitis virus
Giant Cells
Intestinal Mucosa
Hyperplasia
Necrosis
Morbidity
Antigens
Mortality
Antibodies
Infection
Serum
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Barthold, S. W., Smith, A. L., Lord, P. F. S., Bhatt, P. N., Jacoby, R. O., & Main, A. J. (1982). Epizootic coronaviral typhlocolitis in suckling mice. In Laboratory Animal Science (4 ed., Vol. 32, pp. 376-383)

Epizootic coronaviral typhlocolitis in suckling mice. / Barthold, Stephen W; Smith, A. L.; Lord, P. F S; Bhatt, P. N.; Jacoby, R. O.; Main, A. J.

Laboratory Animal Science. Vol. 32 4. ed. 1982. p. 376-383.

Research output: Chapter in Book/Report/Conference proceedingChapter

Barthold, SW, Smith, AL, Lord, PFS, Bhatt, PN, Jacoby, RO & Main, AJ 1982, Epizootic coronaviral typhlocolitis in suckling mice. in Laboratory Animal Science. 4 edn, vol. 32, pp. 376-383.
Barthold SW, Smith AL, Lord PFS, Bhatt PN, Jacoby RO, Main AJ. Epizootic coronaviral typhlocolitis in suckling mice. In Laboratory Animal Science. 4 ed. Vol. 32. 1982. p. 376-383
Barthold, Stephen W ; Smith, A. L. ; Lord, P. F S ; Bhatt, P. N. ; Jacoby, R. O. ; Main, A. J. / Epizootic coronaviral typhlocolitis in suckling mice. Laboratory Animal Science. Vol. 32 4. ed. 1982. pp. 376-383
@inbook{d11b5fb542d941d88a394fbba77eb6d7,
title = "Epizootic coronaviral typhlocolitis in suckling mice",
abstract = "Multiple epizootics of typhlocolitis associated with high morbidity and mortality occurred among suckling mice in an arbovirology research laboratory. Affected mice had necrosis and hyperplasia of cecal, colonic, and less often, small intestinal mucosa. Epithelial syncytia were present throughout the affected areas. Other organs generally were not involved. The etiologic agent was a coronavirus antigenically related to mouse hepatitis virus strains 1 and S. Sera from dams of affected litters and recovered animals did not contain detectable complement fixing antibody to coronavirus antigen. The lesions and the causative agent differed from previously reported coronaviral syndromes in mice. The source of the infection was not definitely found.",
author = "Barthold, {Stephen W} and Smith, {A. L.} and Lord, {P. F S} and Bhatt, {P. N.} and Jacoby, {R. O.} and Main, {A. J.}",
year = "1982",
language = "English (US)",
volume = "32",
pages = "376--383",
booktitle = "Laboratory Animal Science",
edition = "4",

}

TY - CHAP

T1 - Epizootic coronaviral typhlocolitis in suckling mice

AU - Barthold, Stephen W

AU - Smith, A. L.

AU - Lord, P. F S

AU - Bhatt, P. N.

AU - Jacoby, R. O.

AU - Main, A. J.

PY - 1982

Y1 - 1982

N2 - Multiple epizootics of typhlocolitis associated with high morbidity and mortality occurred among suckling mice in an arbovirology research laboratory. Affected mice had necrosis and hyperplasia of cecal, colonic, and less often, small intestinal mucosa. Epithelial syncytia were present throughout the affected areas. Other organs generally were not involved. The etiologic agent was a coronavirus antigenically related to mouse hepatitis virus strains 1 and S. Sera from dams of affected litters and recovered animals did not contain detectable complement fixing antibody to coronavirus antigen. The lesions and the causative agent differed from previously reported coronaviral syndromes in mice. The source of the infection was not definitely found.

AB - Multiple epizootics of typhlocolitis associated with high morbidity and mortality occurred among suckling mice in an arbovirology research laboratory. Affected mice had necrosis and hyperplasia of cecal, colonic, and less often, small intestinal mucosa. Epithelial syncytia were present throughout the affected areas. Other organs generally were not involved. The etiologic agent was a coronavirus antigenically related to mouse hepatitis virus strains 1 and S. Sera from dams of affected litters and recovered animals did not contain detectable complement fixing antibody to coronavirus antigen. The lesions and the causative agent differed from previously reported coronaviral syndromes in mice. The source of the infection was not definitely found.

UR - http://www.scopus.com/inward/record.url?scp=0020324489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020324489&partnerID=8YFLogxK

M3 - Chapter

VL - 32

SP - 376

EP - 383

BT - Laboratory Animal Science

ER -