Epithelioid hemangioendothelioma of bone

Robert D Boutin, H. Joseph Spaeth, Aroop Mangalik, James J. Sell

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Neoplasms of bone can arise from any of the cellular elements that constitute osseous tissues. Although tumors of vascular origin are not uncommon, the vast majority are benign. A rare malignant vascular tumor - epithelioid hemangioendothelioma of bone - classifically affects young males and produces osteolytic lesions involving the cortex and cancellous bone of the lower extremities. We present a case with these findings, as well as such unusual findings as cervical spine instability and lesions affecting no fewer than 45 different bones. We conclude that epithelioid hemangioendothelioma should be investigated by skeletal survey because (1) osteolytic lesions involving more that 50% of the cortex present a serious risk for pathologic fracture and (2) the natural history of multicentric epithelioid hemangioendothelioma is more indolent than its solitary counterparts.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalSkeletal Radiology
Issue number4
StatePublished - May 1996
Externally publishedYes


  • Cortical lesions
  • Epithelioid hemangioendothelioma
  • Neoplasms
  • Vascular bone tumors

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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