Abstract
Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1113-1127 |
| Number of pages | 15 |
| Journal | Future Oncology |
| Volume | 5 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 1 2009 |
Keywords
- E-cadherin
- Epithelial-mesenchymal transition
- Genetically engineered mice
- Heterogeneity
- Invasion
- Metastasis
- Mouse mammary tumors
- Pathology
- Snail
- Spindle cell phenotype
ASJC Scopus subject areas
- Oncology
- Cancer Research