Epithelial-mesenchymal transition in mouse mammary tumorigenesis

Enrico Radaelli, Patrizia Damonte, Robert Cardiff

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.

Original languageEnglish (US)
Pages (from-to)1113-1127
Number of pages15
JournalFuture Oncology
Volume5
Issue number8
DOIs
StatePublished - Dec 1 2009

Fingerprint

Epithelial-Mesenchymal Transition
Carcinogenesis
Breast
Human Mammary Glands
Molecular Biology
Breast Neoplasms
Neoplasms

Keywords

  • E-cadherin
  • Epithelial-mesenchymal transition
  • Genetically engineered mice
  • Heterogeneity
  • Invasion
  • Metastasis
  • Mouse mammary tumors
  • Pathology
  • Snail
  • Spindle cell phenotype

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Epithelial-mesenchymal transition in mouse mammary tumorigenesis. / Radaelli, Enrico; Damonte, Patrizia; Cardiff, Robert.

In: Future Oncology, Vol. 5, No. 8, 01.12.2009, p. 1113-1127.

Research output: Contribution to journalReview article

Radaelli, Enrico ; Damonte, Patrizia ; Cardiff, Robert. / Epithelial-mesenchymal transition in mouse mammary tumorigenesis. In: Future Oncology. 2009 ; Vol. 5, No. 8. pp. 1113-1127.
@article{b9ca382ccd274a658c42764f05ed5dcc,
title = "Epithelial-mesenchymal transition in mouse mammary tumorigenesis",
abstract = "Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.",
keywords = "E-cadherin, Epithelial-mesenchymal transition, Genetically engineered mice, Heterogeneity, Invasion, Metastasis, Mouse mammary tumors, Pathology, Snail, Spindle cell phenotype",
author = "Enrico Radaelli and Patrizia Damonte and Robert Cardiff",
year = "2009",
month = "12",
day = "1",
doi = "10.2217/fon.09.93",
language = "English (US)",
volume = "5",
pages = "1113--1127",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "8",

}

TY - JOUR

T1 - Epithelial-mesenchymal transition in mouse mammary tumorigenesis

AU - Radaelli, Enrico

AU - Damonte, Patrizia

AU - Cardiff, Robert

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.

AB - Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.

KW - E-cadherin

KW - Epithelial-mesenchymal transition

KW - Genetically engineered mice

KW - Heterogeneity

KW - Invasion

KW - Metastasis

KW - Mouse mammary tumors

KW - Pathology

KW - Snail

KW - Spindle cell phenotype

UR - http://www.scopus.com/inward/record.url?scp=75649142093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75649142093&partnerID=8YFLogxK

U2 - 10.2217/fon.09.93

DO - 10.2217/fon.09.93

M3 - Review article

C2 - 19852725

AN - SCOPUS:75649142093

VL - 5

SP - 1113

EP - 1127

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 8

ER -