Abstract
Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1113-1127 |
| Number of pages | 15 |
| Journal | Future Oncology |
| Volume | 5 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 1 2009 |
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Keywords
- E-cadherin
- Epithelial-mesenchymal transition
- Genetically engineered mice
- Heterogeneity
- Invasion
- Metastasis
- Mouse mammary tumors
- Pathology
- Snail
- Spindle cell phenotype
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Epithelial-mesenchymal transition in mouse mammary tumorigenesis. / Radaelli, Enrico; Damonte, Patrizia; Cardiff, Robert.
In: Future Oncology, Vol. 5, No. 8, 01.12.2009, p. 1113-1127.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Epithelial-mesenchymal transition in mouse mammary tumorigenesis
AU - Radaelli, Enrico
AU - Damonte, Patrizia
AU - Cardiff, Robert
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
AB - Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
KW - E-cadherin
KW - Epithelial-mesenchymal transition
KW - Genetically engineered mice
KW - Heterogeneity
KW - Invasion
KW - Metastasis
KW - Mouse mammary tumors
KW - Pathology
KW - Snail
KW - Spindle cell phenotype
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UR - http://www.scopus.com/inward/citedby.url?scp=75649142093&partnerID=8YFLogxK
U2 - 10.2217/fon.09.93
DO - 10.2217/fon.09.93
M3 - Review article
C2 - 19852725
AN - SCOPUS:75649142093
VL - 5
SP - 1113
EP - 1127
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 8
ER -