Epithelial-mesenchymal transition in mouse mammary tumorigenesis

Enrico Radaelli, Patrizia Damonte, Robert Cardiff

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.

Original languageEnglish (US)
Pages (from-to)1113-1127
Number of pages15
JournalFuture Oncology
Volume5
Issue number8
DOIs
StatePublished - Dec 1 2009

Keywords

  • E-cadherin
  • Epithelial-mesenchymal transition
  • Genetically engineered mice
  • Heterogeneity
  • Invasion
  • Metastasis
  • Mouse mammary tumors
  • Pathology
  • Snail
  • Spindle cell phenotype

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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