Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice

Nengjun Yi, Sally Chiu, David B. Allison, Janis S. Fisler, Craig H Warden

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

BSB mice exhibit a wide range of obesity despite being produced by a backcross of lean C57BL/6J (B) × lean Mus spretus (SPRET/Pt) F1 animals × B. Previous linkage studies identified a quantitative trait locus (QTL) on mouse chromosome 7 with coincident peaks for hepatic lipase activity, obesity, and plasma cholesterol. However, these mice were not analyzed for gene × gene epistasis. Hepatic lipase activity is correlated with obesity and plasma cholesterol levels. In this study, we identified QTLs for plasma hepatic lipase activity with three statistical mapping methods: maximum likelihood interval mapping, Bayesian nonepistatic mapping, and Bayesian epistatic mapping. Bayesian epistatic mapping detected not only the QTL on chromosome 7 but also an additional QTL on chromosome 3, which has a weak main effect but a strong interaction with chromosome 7. SPRET/Pt alleles of the QTL on each chromosome promote hepatic lipase activity. The proportion of phenotypic variance explained by the epistatic effect is higher than that explained by the main effect of the QTL on chromosome.

Original languageEnglish (US)
Pages (from-to)2063-2070
Number of pages8
JournalJournal of Lipid Research
Volume45
Issue number11
DOIs
StatePublished - Nov 2004

Keywords

  • Bayesian
  • Gene × gene
  • Hepatic lipase
  • Mouse
  • Obesity
  • Quantitative trait locus

ASJC Scopus subject areas

  • Endocrinology

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