Epilepsy therapy development: Technical and methodologic issues in studies with animal models

Aristea S. Galanopoulou, Merab Kokaia, Jeffrey A. Loeb, Astrid Nehlig, Asla Pitkänen, Michael A Rogawski, Kevin J. Staley, Vicky H. Whittemore, F. Edward Dudek

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact of potential new treatments on epilepsies and comorbidities in humans, using the available resources. Herein we provide a summary of the discussions and proposals of the Working Group 2 as presented in the Joint American Epilepsy Society and International League Against Epilepsy Translational Workshop in London (September 2012). We propose methodologic and reporting practices that will enhance the uniformity, reliability, and reporting of early stage preclinical studies with animal seizure and epilepsy models that aim to develop and evaluate new therapies for seizures or epilepsies, using multidisciplinary approaches. The topics considered include the following: (1) implementation of better study design and reporting practices; (2) incorporation Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)13-23
Number of pages11
JournalEpilepsia
Volume54
Issue numberSUPPL.4
DOIs
StatePublished - Aug 2013

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Keywords

  • Infrastructure.
  • Nonpharmacological treatment
  • Pharmacokinetics
  • Regulatory requirements
  • Tolerability
  • Video-electroencephalography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Galanopoulou, A. S., Kokaia, M., Loeb, J. A., Nehlig, A., Pitkänen, A., Rogawski, M. A., Staley, K. J., Whittemore, V. H., & Dudek, F. E. (2013). Epilepsy therapy development: Technical and methodologic issues in studies with animal models. Epilepsia, 54(SUPPL.4), 13-23. https://doi.org/10.1111/epi.12295