Epilepsy in autism spectrum disorders

Carl E. Stafstrom, Paul J Hagerman, Isaac N Pessah

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Epilepsy occurs frequently in individuals with autism spectrum disorders (ASDs). However, the mechanisms responsible for increased seizure susceptibility in ASDs are largely unknown. Clues to neural hyperexcitability in the autistic brain might be derived from disorders in which single gene mutations cause both epilepsy and an autistic phenotype, such as fragile X syndrome. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).

Original languageEnglish (US)
Pages (from-to)78
Number of pages1
JournalEpilepsia
Volume51
Issue numberSUPPL. 5
DOIs
StatePublished - Dec 2010

Keywords

  • Fragile X syndrome
  • Idiopathic ASD
  • Metabotropic glutamate receptor
  • mTOR
  • Seizures
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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