Epilepsy and EEG findings in males with fragile X syndrome

S. A. Musumeci, Randi J Hagerman, R. Ferri, P. Bosco, B. Dalla Bernardina, C. A. Tassinari, G. B. De Sarro, M. Elia

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Purpose and Methods: One hundred and ninety-two fragile X male patients were investigated for seizures and EEG findings, 168 in a retrospective and 24 in another prospective study, to characterize the natural history of seizures, epilepsy, and EEG abnormalities in males with this syndrome. Results: Seizures were documented in 35 (18.2%) of 192 patients; they never started before the age of 2 years or after the age of 9 years. Seizures were frequently of the complex partial type and less frequently of the partial motor and generalized type. Seizures involving frontal and temporal lobes were commonly seen and were usually well controlled by anticonvulsants. In the majority of young fragile X patients studied, an age-related paroxysmal EEG pattern was found, which showed neurophysiologic characteristics very similar to those of the centrotemporal spikes. Conclusions: These findings confirm that fragile X syndrome can be considered a genetic model of epilepsy.

Original languageEnglish (US)
Pages (from-to)1092-1099
Number of pages8
JournalEpilepsia
Volume40
Issue number8
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Fragile X Syndrome
Electroencephalography
Epilepsy
Seizures
Genetic Models
Frontal Lobe
Temporal Lobe
Anticonvulsants
Prospective Studies

Keywords

  • Centrotemporal spikes
  • EEG
  • Epilepsy
  • FMR-1 gene
  • Fragile X syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Musumeci, S. A., Hagerman, R. J., Ferri, R., Bosco, P., Dalla Bernardina, B., Tassinari, C. A., ... Elia, M. (1999). Epilepsy and EEG findings in males with fragile X syndrome. Epilepsia, 40(8), 1092-1099. https://doi.org/10.1111/j.1528-1157.1999.tb00824.x

Epilepsy and EEG findings in males with fragile X syndrome. / Musumeci, S. A.; Hagerman, Randi J; Ferri, R.; Bosco, P.; Dalla Bernardina, B.; Tassinari, C. A.; De Sarro, G. B.; Elia, M.

In: Epilepsia, Vol. 40, No. 8, 1999, p. 1092-1099.

Research output: Contribution to journalArticle

Musumeci, SA, Hagerman, RJ, Ferri, R, Bosco, P, Dalla Bernardina, B, Tassinari, CA, De Sarro, GB & Elia, M 1999, 'Epilepsy and EEG findings in males with fragile X syndrome', Epilepsia, vol. 40, no. 8, pp. 1092-1099. https://doi.org/10.1111/j.1528-1157.1999.tb00824.x
Musumeci SA, Hagerman RJ, Ferri R, Bosco P, Dalla Bernardina B, Tassinari CA et al. Epilepsy and EEG findings in males with fragile X syndrome. Epilepsia. 1999;40(8):1092-1099. https://doi.org/10.1111/j.1528-1157.1999.tb00824.x
Musumeci, S. A. ; Hagerman, Randi J ; Ferri, R. ; Bosco, P. ; Dalla Bernardina, B. ; Tassinari, C. A. ; De Sarro, G. B. ; Elia, M. / Epilepsy and EEG findings in males with fragile X syndrome. In: Epilepsia. 1999 ; Vol. 40, No. 8. pp. 1092-1099.
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