Epigenetics and Fibrosis: Lessons, Challenges, and Windows of Opportunity

Bin Liu, Xin Sheng Wang, Hui Min Chen, Lu Qianjin, M. Eric Gershwin, Patrick S Leung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fibrosis is a serious health problem characterized by overgrowth, hardening, and/or scarring of tissues, due to excess accumulation of extracellular matrix and could lead to organ malfunction. Fibrotic diseases include a wide spectrum of clinical entities of unknown etiology. Although no effective antifibrotic treatment is available, increasing evidence has demonstrated the involvement of epigenetics. The clinical management of fibrotic diseases is largely hindered by the lack of disease-specific diagnosis biomarkers and therapeutic targets. Here we review recent studies on the epigenetic regulation of fibrosis, with emphasis on fibrosis of the lung, liver, and skin. Epigenetic control of the cellular phenotype in the context of tissue injury and aberrant tissue remodeling offers new insights into the pathogenesis of fibrosis. Knowledge gained on epigenetic regulation provides promising leads for the development of precise predictive diagnosis markers and possibly targeted therapy in the future.

Original languageEnglish (US)
Title of host publicationEpigenetics and Dermatology
PublisherElsevier Inc.
Pages53-74
Number of pages22
ISBN (Print)9780128012727, 9780128009574
DOIs
StatePublished - Feb 17 2015

Keywords

  • DNA methylation
  • Epigenetics
  • Fibrosis
  • Histone modifications
  • Liver
  • Lung
  • Skin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Liu, B., Wang, X. S., Chen, H. M., Qianjin, L., Gershwin, M. E., & Leung, P. S. (2015). Epigenetics and Fibrosis: Lessons, Challenges, and Windows of Opportunity. In Epigenetics and Dermatology (pp. 53-74). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800957-4.00004-7