Epigenetic Mechanisms of Sirtuins in Dermatology

Alexander Lo, Melissa Serravallo, Jared Jagdeo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sirtuins are a family of mammalian histone deacetylases that have been studied as possible antiaging epigenetic regulators and were shown more recently to be involved in many processes relating to the field of dermatology. Herein we describe the epigenetic roles that sirtuins play in dermatology. Research implicates sirtuin function is crucial to dermatological diseases including skin aging, inflammatory skin diseases, hyperproliferative disease, scarring, skin cancer, and skin-related inherited diseases. We will highlight the epigenetic basis for sirtuin function in various cellular processes and investigate the potential role of sirtuin modulation in the development of novel epigenetic therapies in dermatology.

Original languageEnglish (US)
Title of host publicationEpigenetics and Dermatology
PublisherElsevier Inc.
Pages137-175
Number of pages39
ISBN (Print)9780128012727, 9780128009574
DOIs
StatePublished - Feb 17 2015

Keywords

  • Adenosine diphosphate ribosyl transferase
  • Aging
  • Dermatology
  • Epigenetic
  • Histone deacetylase
  • Photoaging
  • SIRT
  • Sirtuins
  • Skin
  • Skin cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Lo, A., Serravallo, M., & Jagdeo, J. (2015). Epigenetic Mechanisms of Sirtuins in Dermatology. In Epigenetics and Dermatology (pp. 137-175). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800957-4.00008-4