Epigenetic layers and players underlying neurodevelopment

Janine M LaSalle, Weston T. Powell, Dag H. Yasui

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Epigenetic mechanisms convey information above and beyond the sequence of DNA, so it is predicted that they are critical in the complex regulation of brain development and explain the long-lived effects of environmental cues on pre- and early post-natal brain development. Neurons have a complex epigenetic landscape that changes dynamically with transcriptional activity in early life. Here, we summarize progress in our understanding of the discrete layers of the dynamic methylome, chromatin proteome, noncoding RNAs, chromatin loops, and long-range interactions in neuronal development and maturation. Many neurodevelopmental disorders have genetic alterations in these epigenetic modifications or regulators, and these human genetics lessons have demonstrated the importance of these epigenetic players and the epigenetic layers that transcriptional events lay down in the early brain.

Original languageEnglish (US)
Pages (from-to)460-470
Number of pages11
JournalTrends in Neurosciences
Volume36
Issue number8
DOIs
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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