Epigenetic control of skeletal muscle fibre type

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Adult muscle is extremely plastic. However, the muscle precursor cells associated with those fibres show stable and heritable differences in gene expression indicative of epigenetic imprinting. Epigenetic processes in the development of skeletal muscle have been appreciated for over a decade; however, there are a paucity of studies looking at whether epigenetics determines the phenotype of adult and/or ageing skeletal muscle. This review presents the evidence that epigenetics plays a role in determining adult muscle function and a series of unanswered questions that would greatly increase our understanding of how epigenetics works in adult muscle. With the increased interest in epigenetics, over the next few years this field will begin to unfold in unimaginable directions.

Original languageEnglish (US)
Pages (from-to)477-487
Number of pages11
JournalActa Physiologica
Volume199
Issue number4
DOIs
StatePublished - 2010

Keywords

  • acetylation
  • DNA methylation
  • exercise

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)

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