Epigallocatechin gallate attenuates overload-induced cardiac ECM remodeling via restoring T cell homeostasis

Yongsheng Han, Qingtong Wang, Xizhen Fan, Jun Chu, Junfu Peng, Yousheng Zhu, Yan Li, Xiaojing Li, Lei Shen, James Asenso, Shanfeng Li

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


It has previously been demonstrated that Epigallocatechin gallate (EGCG) has regulatory effects on cellular immunity. The present study explored whether EGCG inhibits the overload-induced cardiac extracellular matrix (ECM) remodeling through targeting the balance of T cell subpopulations. Sprague-Dawley rats were subjected to either transverse aortic constriction (TAC) or sham operation. TAC rats were treated with EGCG or valsartan (Val) for 6 weeks. The administration of EGCG or Val ameliorated the overproduction of cardiac collagen, inhibited matrix metalloproteinase (MMP) activity, decreased the expression of tissue inhibitor of MMP-2, atrial natriuretic peptide and brain natriuretic peptide. EGCG regulated the population of effector T cells and naïve T cells, restored the balance of T helper (Th) cell 17/regulatory T cells, via modulating the downstream regulator signal transducer and activator of transcription (STAT3) and STAT5. Furthermore, the ratio of interferon-γ/interleukin (IL)-10 which indicates the balance of Th1/Th2, was restored by the treatments at varying degrees. EGCG and Val administration rescued IL-7 production, and decreased the level of IL-15 in TAC rats. EGCG has positive therapeutic potential in inhibiting cardiac ECM remodeling. Regulation of the balance of T lymphocyte subsets may be one of the underlying mechanisms responsible for this effect.

Original languageEnglish (US)
Pages (from-to)3542-3550
Number of pages9
JournalMolecular Medicine Reports
Issue number3
StatePublished - Sep 1 2017
Externally publishedYes


  • Cardiac remodeling
  • Epigallocatechin gallate
  • Immunological regulation
  • Regulatory T cells
  • T helper cell 17

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research


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