Epidermal stem cells: An update on their potential in regenerative medicine

Xiaoyan Sun, Xiaobing Fu, Weidong Han, Min Zhao, Laura Chalmers

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Introduction: Adult epidermal stem cells are crucial for skin tissue regeneration during homeostasis and disease. Recent updates relating to the function, cellular role and properties of these cells have been published. Notably, a recent study showed that keratinocytes may possess a transcriptional profile that is more amenable to reprogramming and this may open new avenues for exploring novel strategies to create patient-specific cell therapies. Areas covered: In this paper, an overview of recent research pertaining to epidermal stem cells' properties and location, and their capacity for differentiation and transdifferentiation, as well as potential for tumorigenesis are presented. Expert opinion: More efforts should be made to develop effective approaches to induce lineage conversion between different cell types and tailor the treatment to specific patient, while minimizing cancer risk.

Original languageEnglish (US)
Pages (from-to)901-910
Number of pages10
JournalExpert Opinion on Biological Therapy
Volume13
Issue number6
DOIs
StatePublished - 2013

Keywords

  • Differentiation
  • Direct conversion
  • Epidermal stem cells
  • Induced pluripotent stem cells
  • Transdifferentiation
  • Tumorigenesis

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery
  • Medicine(all)

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