Epidemiology of cancer-related venous thromboembolism

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

Recent studies have better defined the epidemiology of venous thromboembolism (VTE) in cancer patients. The incidence is highest in patients who have metastatic disease at the time of presentation and who have fast growing, biologically aggressive cancers associated with a poor prognosis. The incidence is also high in patients with haematological cancers. Other specific risk factors that affect the incidence of VTE include undergoing invasive neurosurgery, the number of underlying chronic co-morbid conditions, and being of Asian/Pacific Islander decent (lower incidence). The incidence is highest in the first few months after diagnosis, which may reflect the biology of the cancer or medical interventions such as major surgery or start of chemotherapy. The development of VTE is clearly associated with decreased survival, and this effect is greater among patients initially diagnosed with local- or regional-stage cancer compared with patients with metastatic cancer, probably because VTE reflects the presence of a biologically aggressive cancer. Finally, a small percentage of patients with idiopathic VTE and no clinical or laboratory evidence of cancer may harbour an aggressive but 'occult' malignancy likely causally linked to the development of VTE.

Original languageEnglish (US)
Pages (from-to)9-23
Number of pages15
JournalBest Practice and Research: Clinical Haematology
Volume22
Issue number1
DOIs
StatePublished - Mar 2009

Keywords

  • epidemiology
  • ethnicity
  • pulmonary embolism
  • race
  • thromboembolism
  • venous thrombosis

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

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