Epidemiology of bartonella infection in rodents and shrews in Taiwan

J. W. Hsieh, K. C. Tung, W. C. Chen, J. W. Lin, L. J. Chien, Y. M. Hsu, H. C. Wang, Bruno B Chomel, C. C. Chang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

During the period of August 2002 and November 2004, an epidemiological investigation for Bartonella infection was conducted in small mammals in Taiwan. Using whole blood culture on chocolate agar plates, Bartonella species were successfully isolated from 41.3% of the 310 animals tested. The isolation rate of Bartonella species varied among different animal species, including 52.7% of the 169 Rattus norvegicus, 28.6% of the 126 Sucus murinus, 10% of the 10 Rattus rattus and 66.7% of the three Rattus losea. Bacteremia prevalence also varied with the origin of the animals, as 56.2% of the animals captured on farms, 38.6% of the ones captured at harbour sites and 11.8% of the animals captured from urban areas were bacteremic. Through molecular analysis of the gltA gene and 16S23S intergenic spacer region, genetic diversity of Bartonella organisms was identified, including strains closely related to Bartonella tribocorum, Bartonella grahamii, Bartonella elizabethae, Bartonella phoceensis and Bartonella rattimassiliensis. Moreover, this is the first report of zoonotic B. elizabethae and B. grahamii identified in R. losea, the lesser rice-field rat. Various Bartonella species were identified in R. norvegicus, compared to 97.2% of Suncus murinus with unique Bartonella species. By indirect immunofluorescence antibody test, using various rodent Bartonella species as antigens, consistently low percentage of seropositivity implied that small mammals may play a role as competent reservoirs of Bartonella species in Taiwan. Future studies need to be conducted to determine whether these Bartonella species would be responsible for human cases of unknown fever or febrile illness in Taiwan, especially zoonotic B. elizabethae and B. grahamii.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalZoonoses and Public Health
Volume57
Issue number6
DOIs
StatePublished - Sep 2010

Fingerprint

Bartonella Infections
Bartonella
Shrews
shrews
Taiwan
epidemiology
Rodentia
Epidemiology
rodents
Bartonella grahamii
Bartonella elizabethae
infection
Rattus norvegicus
animals
small mammals
Zoonoses
fever
Bartonella tribocorum
Mammals
Suncus murinus

Keywords

  • Bartonella species
  • epidemiology
  • Rattus losea
  • small mammals

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Hsieh, J. W., Tung, K. C., Chen, W. C., Lin, J. W., Chien, L. J., Hsu, Y. M., ... Chang, C. C. (2010). Epidemiology of bartonella infection in rodents and shrews in Taiwan. Zoonoses and Public Health, 57(6), 439-446. https://doi.org/10.1111/j.1863-2378.2009.01234.x

Epidemiology of bartonella infection in rodents and shrews in Taiwan. / Hsieh, J. W.; Tung, K. C.; Chen, W. C.; Lin, J. W.; Chien, L. J.; Hsu, Y. M.; Wang, H. C.; Chomel, Bruno B; Chang, C. C.

In: Zoonoses and Public Health, Vol. 57, No. 6, 09.2010, p. 439-446.

Research output: Contribution to journalArticle

Hsieh, JW, Tung, KC, Chen, WC, Lin, JW, Chien, LJ, Hsu, YM, Wang, HC, Chomel, BB & Chang, CC 2010, 'Epidemiology of bartonella infection in rodents and shrews in Taiwan', Zoonoses and Public Health, vol. 57, no. 6, pp. 439-446. https://doi.org/10.1111/j.1863-2378.2009.01234.x
Hsieh, J. W. ; Tung, K. C. ; Chen, W. C. ; Lin, J. W. ; Chien, L. J. ; Hsu, Y. M. ; Wang, H. C. ; Chomel, Bruno B ; Chang, C. C. / Epidemiology of bartonella infection in rodents and shrews in Taiwan. In: Zoonoses and Public Health. 2010 ; Vol. 57, No. 6. pp. 439-446.
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abstract = "During the period of August 2002 and November 2004, an epidemiological investigation for Bartonella infection was conducted in small mammals in Taiwan. Using whole blood culture on chocolate agar plates, Bartonella species were successfully isolated from 41.3{\%} of the 310 animals tested. The isolation rate of Bartonella species varied among different animal species, including 52.7{\%} of the 169 Rattus norvegicus, 28.6{\%} of the 126 Sucus murinus, 10{\%} of the 10 Rattus rattus and 66.7{\%} of the three Rattus losea. Bacteremia prevalence also varied with the origin of the animals, as 56.2{\%} of the animals captured on farms, 38.6{\%} of the ones captured at harbour sites and 11.8{\%} of the animals captured from urban areas were bacteremic. Through molecular analysis of the gltA gene and 16S23S intergenic spacer region, genetic diversity of Bartonella organisms was identified, including strains closely related to Bartonella tribocorum, Bartonella grahamii, Bartonella elizabethae, Bartonella phoceensis and Bartonella rattimassiliensis. Moreover, this is the first report of zoonotic B. elizabethae and B. grahamii identified in R. losea, the lesser rice-field rat. Various Bartonella species were identified in R. norvegicus, compared to 97.2{\%} of Suncus murinus with unique Bartonella species. By indirect immunofluorescence antibody test, using various rodent Bartonella species as antigens, consistently low percentage of seropositivity implied that small mammals may play a role as competent reservoirs of Bartonella species in Taiwan. Future studies need to be conducted to determine whether these Bartonella species would be responsible for human cases of unknown fever or febrile illness in Taiwan, especially zoonotic B. elizabethae and B. grahamii.",
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