Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus)

Susan K. Mikota, Linda Peddie, James Peddie, Ramiro Isaza, Freeland Dunker, Gary West, William Lindsay, R. Scott Larsen, M. D. Salman, Delphi Chatterjee, Janet Payeur, Diana Whipple, Charles Thoen, Donald S. Davis, Charles Sedgwick, Richard J. Montali, Michael H Ziccardi, Joel Maslow

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The deaths of two Asian elephants (Elephas maximus) in August 1996 led the United States Department of Agriculture to require the testing and treatment of elephants for tuberculosis. From August 1996 to September 1999, Mycobacterium tuberculosis infection was confirmed by culture in 12 of 118 elephants in six herds. Eight diagnoses were made antemortem on the basis of isolation of M. tuberculosis by culture of trunk wash samples; the remainder (including the initial two) were diagnosed postmortem. We present the case histories, epidemiologic characteristics, diagnostic test results, and therapeutic plans from these six herds. The intradermal tuberculin test, enzyme-linked immunosorbent assay serology, the blood tuberculosis test, and nucleic acid amplification and culture are compared as methods to diagnose M. tuberculosis infection in elephants.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalJournal of Zoo and Wildlife Medicine
Volume32
Issue number1
StatePublished - 2001

Fingerprint

Elephas maximus
tuberculosis
Elephantidae
Mycobacterium tuberculosis
elephant
epidemiology
Epidemiology
herds
Mycobacterium Infections
tuberculin
testing
Tuberculosis
USDA
infection
diagnostic techniques
nucleic acids
Intradermal Tests
United States Department of Agriculture
Tuberculin Test
enzyme-linked immunosorbent assay

Keywords

  • Elephant
  • Elephas maximus
  • Loxodonta africana
  • Mycobacterium tuberculosis
  • Tuberculin test
  • Tuberculosis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Environmental Science(all)
  • veterinary(all)

Cite this

Mikota, S. K., Peddie, L., Peddie, J., Isaza, R., Dunker, F., West, G., ... Maslow, J. (2001). Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus). Journal of Zoo and Wildlife Medicine, 32(1), 1-16.

Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus). / Mikota, Susan K.; Peddie, Linda; Peddie, James; Isaza, Ramiro; Dunker, Freeland; West, Gary; Lindsay, William; Larsen, R. Scott; Salman, M. D.; Chatterjee, Delphi; Payeur, Janet; Whipple, Diana; Thoen, Charles; Davis, Donald S.; Sedgwick, Charles; Montali, Richard J.; Ziccardi, Michael H; Maslow, Joel.

In: Journal of Zoo and Wildlife Medicine, Vol. 32, No. 1, 2001, p. 1-16.

Research output: Contribution to journalArticle

Mikota, SK, Peddie, L, Peddie, J, Isaza, R, Dunker, F, West, G, Lindsay, W, Larsen, RS, Salman, MD, Chatterjee, D, Payeur, J, Whipple, D, Thoen, C, Davis, DS, Sedgwick, C, Montali, RJ, Ziccardi, MH & Maslow, J 2001, 'Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus)', Journal of Zoo and Wildlife Medicine, vol. 32, no. 1, pp. 1-16.
Mikota, Susan K. ; Peddie, Linda ; Peddie, James ; Isaza, Ramiro ; Dunker, Freeland ; West, Gary ; Lindsay, William ; Larsen, R. Scott ; Salman, M. D. ; Chatterjee, Delphi ; Payeur, Janet ; Whipple, Diana ; Thoen, Charles ; Davis, Donald S. ; Sedgwick, Charles ; Montali, Richard J. ; Ziccardi, Michael H ; Maslow, Joel. / Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus). In: Journal of Zoo and Wildlife Medicine. 2001 ; Vol. 32, No. 1. pp. 1-16.
@article{c851d803c17b4407a10298865e1d2da2,
title = "Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus)",
abstract = "The deaths of two Asian elephants (Elephas maximus) in August 1996 led the United States Department of Agriculture to require the testing and treatment of elephants for tuberculosis. From August 1996 to September 1999, Mycobacterium tuberculosis infection was confirmed by culture in 12 of 118 elephants in six herds. Eight diagnoses were made antemortem on the basis of isolation of M. tuberculosis by culture of trunk wash samples; the remainder (including the initial two) were diagnosed postmortem. We present the case histories, epidemiologic characteristics, diagnostic test results, and therapeutic plans from these six herds. The intradermal tuberculin test, enzyme-linked immunosorbent assay serology, the blood tuberculosis test, and nucleic acid amplification and culture are compared as methods to diagnose M. tuberculosis infection in elephants.",
keywords = "Elephant, Elephas maximus, Loxodonta africana, Mycobacterium tuberculosis, Tuberculin test, Tuberculosis",
author = "Mikota, {Susan K.} and Linda Peddie and James Peddie and Ramiro Isaza and Freeland Dunker and Gary West and William Lindsay and Larsen, {R. Scott} and Salman, {M. D.} and Delphi Chatterjee and Janet Payeur and Diana Whipple and Charles Thoen and Davis, {Donald S.} and Charles Sedgwick and Montali, {Richard J.} and Ziccardi, {Michael H} and Joel Maslow",
year = "2001",
language = "English (US)",
volume = "32",
pages = "1--16",
journal = "Journal of Zoo and Wildlife Medicine",
issn = "1042-7260",
publisher = "American Association of Zoo Veterinarians",
number = "1",

}

TY - JOUR

T1 - Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus)

AU - Mikota, Susan K.

AU - Peddie, Linda

AU - Peddie, James

AU - Isaza, Ramiro

AU - Dunker, Freeland

AU - West, Gary

AU - Lindsay, William

AU - Larsen, R. Scott

AU - Salman, M. D.

AU - Chatterjee, Delphi

AU - Payeur, Janet

AU - Whipple, Diana

AU - Thoen, Charles

AU - Davis, Donald S.

AU - Sedgwick, Charles

AU - Montali, Richard J.

AU - Ziccardi, Michael H

AU - Maslow, Joel

PY - 2001

Y1 - 2001

N2 - The deaths of two Asian elephants (Elephas maximus) in August 1996 led the United States Department of Agriculture to require the testing and treatment of elephants for tuberculosis. From August 1996 to September 1999, Mycobacterium tuberculosis infection was confirmed by culture in 12 of 118 elephants in six herds. Eight diagnoses were made antemortem on the basis of isolation of M. tuberculosis by culture of trunk wash samples; the remainder (including the initial two) were diagnosed postmortem. We present the case histories, epidemiologic characteristics, diagnostic test results, and therapeutic plans from these six herds. The intradermal tuberculin test, enzyme-linked immunosorbent assay serology, the blood tuberculosis test, and nucleic acid amplification and culture are compared as methods to diagnose M. tuberculosis infection in elephants.

AB - The deaths of two Asian elephants (Elephas maximus) in August 1996 led the United States Department of Agriculture to require the testing and treatment of elephants for tuberculosis. From August 1996 to September 1999, Mycobacterium tuberculosis infection was confirmed by culture in 12 of 118 elephants in six herds. Eight diagnoses were made antemortem on the basis of isolation of M. tuberculosis by culture of trunk wash samples; the remainder (including the initial two) were diagnosed postmortem. We present the case histories, epidemiologic characteristics, diagnostic test results, and therapeutic plans from these six herds. The intradermal tuberculin test, enzyme-linked immunosorbent assay serology, the blood tuberculosis test, and nucleic acid amplification and culture are compared as methods to diagnose M. tuberculosis infection in elephants.

KW - Elephant

KW - Elephas maximus

KW - Loxodonta africana

KW - Mycobacterium tuberculosis

KW - Tuberculin test

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=0043133762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043133762&partnerID=8YFLogxK

M3 - Article

C2 - 12790389

AN - SCOPUS:0043133762

VL - 32

SP - 1

EP - 16

JO - Journal of Zoo and Wildlife Medicine

JF - Journal of Zoo and Wildlife Medicine

SN - 1042-7260

IS - 1

ER -