Epidemiologic assessment of screening tests for antibody to human T lymphotropic virus type I (HTLV-I)

R. F. Khabbaz, T. M. Hartley, Michael Dale Lairmore, J. E. Kaplan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We tested 196 sera from a human T lymphotropic virus type I (HTLV-I) risk group (prostitute women) with two commercial 'research' enzyme-linked immunoabsorbent assays (EIA) for HTLV-I antibodies. All tested sera were characterized by HTLV-I Wester immunoblots and by HTLV-I radioimmunoprecipitation assays. The estimated sensitivities of the EIA tests were 93.8 percent and 100 percent, and the specificities were 98.8 percent and 95.8 percent, respectively, using recommended criteria for seropositivity (requiring reactivity to both gag p24 and env gp46 or gp61/68). Calculated negative predictive values remained excellent (>99.9 percent and 100 percent, respectively) at lower seroprevalence rates but the positive predictive values were only 7.3 percent and 2.3 percent when calculated for a seroprevalence rate of 0.1 percent. These results emphasize the importance and need for additional HTLV-I supplementary serologic testing when screening populations with low HTLV-I seroprevalence rates.

Original languageEnglish (US)
Pages (from-to)190-192
Number of pages3
JournalAmerican Journal of Public Health
Volume80
Issue number2
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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