Abstract
A 4-year-old male Shih Tzu died suddenly with the only history being slight lethargy during the previous 2 days. Gross and histopathological examination of the heart revealed severe segmental stenosis of the epicardial coronary artery branches and extensive areas of acute myocardial necrosis interspersed with areas of fibrosis. The segmental coronary artery stenosis was due to smooth muscle and myofibroblast proliferation in the tunica media. The smooth muscle cells and myofibroblasts disrupted the internal elastic lamina and extended into the tunica intima. Thickening of the intima and media was accompanied by fibrosis, consistent with fibromuscular dysplasia. The resulting stenosis led to myocardial infarction and cardiac insufficiency. This report details for the first time the vascular lesions in a case of sudden cardiac death in a dog afflicted with fibromuscular dysplasia of the coronary arteries.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 78-81 |
| Number of pages | 4 |
| Journal | Journal of Comparative Pathology |
| Volume | 144 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2011 |
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Keywords
- Coronary artery
- Dog
- Fibromuscular dysplasia
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- veterinary(all)
Cite this
Epicardial Coronary Artery Fibromuscular Dysplasia, Myocardial Infarction and Sudden Death in a Dog. / Mete, Asli; McDonough, S. P.
In: Journal of Comparative Pathology, Vol. 144, No. 1, 01.2011, p. 78-81.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epicardial Coronary Artery Fibromuscular Dysplasia, Myocardial Infarction and Sudden Death in a Dog
AU - Mete, Asli
AU - McDonough, S. P.
PY - 2011/1
Y1 - 2011/1
N2 - A 4-year-old male Shih Tzu died suddenly with the only history being slight lethargy during the previous 2 days. Gross and histopathological examination of the heart revealed severe segmental stenosis of the epicardial coronary artery branches and extensive areas of acute myocardial necrosis interspersed with areas of fibrosis. The segmental coronary artery stenosis was due to smooth muscle and myofibroblast proliferation in the tunica media. The smooth muscle cells and myofibroblasts disrupted the internal elastic lamina and extended into the tunica intima. Thickening of the intima and media was accompanied by fibrosis, consistent with fibromuscular dysplasia. The resulting stenosis led to myocardial infarction and cardiac insufficiency. This report details for the first time the vascular lesions in a case of sudden cardiac death in a dog afflicted with fibromuscular dysplasia of the coronary arteries.
AB - A 4-year-old male Shih Tzu died suddenly with the only history being slight lethargy during the previous 2 days. Gross and histopathological examination of the heart revealed severe segmental stenosis of the epicardial coronary artery branches and extensive areas of acute myocardial necrosis interspersed with areas of fibrosis. The segmental coronary artery stenosis was due to smooth muscle and myofibroblast proliferation in the tunica media. The smooth muscle cells and myofibroblasts disrupted the internal elastic lamina and extended into the tunica intima. Thickening of the intima and media was accompanied by fibrosis, consistent with fibromuscular dysplasia. The resulting stenosis led to myocardial infarction and cardiac insufficiency. This report details for the first time the vascular lesions in a case of sudden cardiac death in a dog afflicted with fibromuscular dysplasia of the coronary arteries.
KW - Coronary artery
KW - Dog
KW - Fibromuscular dysplasia
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UR - http://www.scopus.com/inward/citedby.url?scp=78650304663&partnerID=8YFLogxK
U2 - 10.1016/j.jcpa.2010.04.010
DO - 10.1016/j.jcpa.2010.04.010
M3 - Article
C2 - 20538284
AN - SCOPUS:78650304663
VL - 144
SP - 78
EP - 81
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
SN - 0021-9975
IS - 1
ER -