Epicardial Coronary Artery Fibromuscular Dysplasia, Myocardial Infarction and Sudden Death in a Dog

Asli Mete, S. P. McDonough

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 4-year-old male Shih Tzu died suddenly with the only history being slight lethargy during the previous 2 days. Gross and histopathological examination of the heart revealed severe segmental stenosis of the epicardial coronary artery branches and extensive areas of acute myocardial necrosis interspersed with areas of fibrosis. The segmental coronary artery stenosis was due to smooth muscle and myofibroblast proliferation in the tunica media. The smooth muscle cells and myofibroblasts disrupted the internal elastic lamina and extended into the tunica intima. Thickening of the intima and media was accompanied by fibrosis, consistent with fibromuscular dysplasia. The resulting stenosis led to myocardial infarction and cardiac insufficiency. This report details for the first time the vascular lesions in a case of sudden cardiac death in a dog afflicted with fibromuscular dysplasia of the coronary arteries.

Original languageEnglish (US)
Pages (from-to)78-81
Number of pages4
JournalJournal of Comparative Pathology
Volume144
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Fibromuscular Dysplasia
Myofibroblasts
Coronary Stenosis
myocardial infarction
coronary vessels
Sudden Death
Coronary Vessels
Fibrosis
Myocardial Infarction
Dogs
Tunica Intima
death
Tunica Media
fibrosis
smooth muscle
Lethargy
dogs
Sudden Cardiac Death
Smooth Muscle Myocytes
Smooth Muscle

Keywords

  • Coronary artery
  • Dog
  • Fibromuscular dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Epicardial Coronary Artery Fibromuscular Dysplasia, Myocardial Infarction and Sudden Death in a Dog. / Mete, Asli; McDonough, S. P.

In: Journal of Comparative Pathology, Vol. 144, No. 1, 01.2011, p. 78-81.

Research output: Contribution to journalArticle

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