Epicardial and endocardial localized 31P magnetic resonance spectroscopy: Evidence for metabolic heterogeneity during regional ischemia

J. R. Gober, Saul Schaefer, S. A. Camacho, M. DeGroot, R. Obregon, E. H. Botvinick, M. Weiner, B. Massie

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Previous studies have noted that myocardial blood flow and high energy phosphates are heterogeneous across the myocardial wall during ischemia. In order to determine whether differences in metabolites between the subendocardium and subepicardium could be detected using 31P magnetic resonance spectroscopy, the Fourier series window (FSW) experiment was implemented on a porcine model of graded regional ischemia. FSW experiments using a planar phantom showed a 46% improvement in localization to the subendocardium compared to a one-pulse experiment. Animal studies of graded ischemia demonstrated a gradient in the phosphocreatine to inorganic phosphate ratio in the myocardium that paralleled the gradient in blood flow. These studies demonstrate the ability of spatially localized 31P magnetic resonance spectroscopy to detect regional changes in myocardial high energy phosphates localized to the subepicardium and subendocardium.

Original languageEnglish (US)
Pages (from-to)204-215
Number of pages12
JournalMagnetic Resonance in Medicine
Issue number2
StatePublished - 1990

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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