Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleus

Andrew D. Huberman, Karl D Murray, David K. Warland, David A. Feldheim, Barbara Chapman

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped pattern of layers in the LGN. Overexpression of EphAs in ferret RGCs using in vivo electroporation induced axons from both eyes to misproject within the LGN. The effects of EphA overexpression were competition-dependent and restricted to the early postnatal period. These findings represent the first demonstration of eye-specific pathfinding mediated by axon guidance cues and, taken with other reports, indicate that ephrin-As can mediate several mapping functions within individual target structures.

Original languageEnglish (US)
Pages (from-to)1013-1021
Number of pages9
JournalNature Neuroscience
Volume8
Issue number8
DOIs
StatePublished - Aug 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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