EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure

Michael A. Robichaux, George Chenaux, Hsin-Yi Henry Ho, Michael J. Soskis, Michael E. Greenberg, Mark Henkemeyer, Christopher W. Cowan

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The two cortical hemispheres of the mammalian forebrain are interconnected by major white matter tracts, including the corpus callosum (CC) and the posterior branch of the anterior commissure (ACp), that bridge the telencephalic midline. We show here that the intracellular signaling domains of the EphB1 and EphB2 receptors are critical for formation of both the ACp and CC. We observe partial and complete agenesis of the corpus callosum, as well as highly penetrant ACp misprojection phenotypes in truncated EphB1/2 mice that lack intracellular signaling domains. Consistent with the roles for these receptors in formation of the CC and ACp, we detect expression of these receptors in multiple brain regions associated with the formation of these forebrain structures. Taken together, our findings suggest that a combination of forward and reverse EphB1/2 receptor-mediated signaling contribute to ACp and CC axon guidance.

Original languageEnglish (US)
Pages (from-to)405-420
Number of pages16
JournalDevelopmental Neurobiology
Volume76
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Keywords

  • Anterior commissure
  • Axon guidance
  • Corpus callosum
  • EphB
  • Ephrin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

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    Robichaux, M. A., Chenaux, G., Ho, H-Y. H., Soskis, M. J., Greenberg, M. E., Henkemeyer, M., & Cowan, C. W. (2016). EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure. Developmental Neurobiology, 76(4), 405-420. https://doi.org/10.1002/dneu.22323