Eosinophilic keratitis in 46 eyes of 27 horses in the Mid-Atlantic United States (2008-2012)

Mary Utter, Chelsey Miller, Kathryn L. Wotman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To review the signalment, clinical characteristics, treatment, and outcome of equine EK cases in the Mid-Atlantic United States; to evaluate the effects of topical or systemic corticosteroid treatment, oral cetirizine treatment and secondary corneal infection on disease duration; and to evaluate the association between corticosteroid and cetirizine treatment and likelihood of recurrence. Animals: Twenty-seven horses (47 eyes) diagnosed with EK from 2008 to 2012. Procedure: Retrospective medical record review followed by phone interview to obtain recurrence data. Results: Average age of affected horses was 8.2 years, SD 5.8 years. Eleven of 27 horses (41%) were diagnosed with EK in July. Twelve horses (44%) had been affected in previous years. Time to resolution averaged 3.7 months, SD 2.3 months. Ten horses (18 eyes) were treated with systemic dexamethasone, with a significantly shorter time to resolution, P = 0.03, averaging 2.23 months, SD 1.13 months, relative to horses not so treated, averaging 4.20 months, SD 1.47 months. Secondary infection led to a significant increase in time to resolution, P = 0.03, average 4.1 months, SD 1.7 months, relative to horses without secondary infection, average 3.0 months, SD 1.5 months. All eyes were visual at resolution. Horses treated with cetirizine were less likely to have recurrence during the follow-up period (1/13, or 8%) relative to horses not so treated (8/14, or 57%). Conclusions: Eosinophilic keratitis has a seasonal occurrence in summer in the Mid-Atlantic United States. Systemic but not topical corticosteroid treatment may decrease therapy duration. Treatment with cetirizine may be associated with a decreased risk of recurrence.

Original languageEnglish (US)
Pages (from-to)311-320
Number of pages10
JournalVeterinary Ophthalmology
Volume17
Issue number5
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

keratitis
Keratitis
Horses
eyes
horses
Cetirizine
adrenal cortex hormones
Coinfection
Recurrence
Adrenal Cortex Hormones
duration
risk reduction
dexamethasone
Dexamethasone
Medical Records
interviews
mouth
Interviews

Keywords

  • Cetirizine
  • Corticosteroids
  • Eosinophilic
  • Equine
  • Keratitis
  • Recurrence

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Eosinophilic keratitis in 46 eyes of 27 horses in the Mid-Atlantic United States (2008-2012). / Utter, Mary; Miller, Chelsey; Wotman, Kathryn L.

In: Veterinary Ophthalmology, Vol. 17, No. 5, 01.01.2014, p. 311-320.

Research output: Contribution to journalArticle

Utter, Mary ; Miller, Chelsey ; Wotman, Kathryn L. / Eosinophilic keratitis in 46 eyes of 27 horses in the Mid-Atlantic United States (2008-2012). In: Veterinary Ophthalmology. 2014 ; Vol. 17, No. 5. pp. 311-320.
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abstract = "Objective: To review the signalment, clinical characteristics, treatment, and outcome of equine EK cases in the Mid-Atlantic United States; to evaluate the effects of topical or systemic corticosteroid treatment, oral cetirizine treatment and secondary corneal infection on disease duration; and to evaluate the association between corticosteroid and cetirizine treatment and likelihood of recurrence. Animals: Twenty-seven horses (47 eyes) diagnosed with EK from 2008 to 2012. Procedure: Retrospective medical record review followed by phone interview to obtain recurrence data. Results: Average age of affected horses was 8.2 years, SD 5.8 years. Eleven of 27 horses (41{\%}) were diagnosed with EK in July. Twelve horses (44{\%}) had been affected in previous years. Time to resolution averaged 3.7 months, SD 2.3 months. Ten horses (18 eyes) were treated with systemic dexamethasone, with a significantly shorter time to resolution, P = 0.03, averaging 2.23 months, SD 1.13 months, relative to horses not so treated, averaging 4.20 months, SD 1.47 months. Secondary infection led to a significant increase in time to resolution, P = 0.03, average 4.1 months, SD 1.7 months, relative to horses without secondary infection, average 3.0 months, SD 1.5 months. All eyes were visual at resolution. Horses treated with cetirizine were less likely to have recurrence during the follow-up period (1/13, or 8{\%}) relative to horses not so treated (8/14, or 57{\%}). Conclusions: Eosinophilic keratitis has a seasonal occurrence in summer in the Mid-Atlantic United States. Systemic but not topical corticosteroid treatment may decrease therapy duration. Treatment with cetirizine may be associated with a decreased risk of recurrence.",
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