Enzyme histochemical characteristics of spontaneous and induced hepatocellular neoplasms in mice

Boris H. Ruebner, M. Eric Gershwin, Earl F. Meierhenry, Pat Dunn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hepatocellular neoplasms are known to differ in enzyme activity from the surrounding non-neoplastic liver. We have compared histochemically the enzyme activity of spontaneous hepatocellular tumors in mice with tumors induced by diethylnitrosamine and dieldrin. Some neoplasms had increased activity, others had decreased enzyme activity, yet others had the same activity as the surrounding liver. Alkaline phosphatase, glucose-6-phosphatase, succinic dehydrogenase and adenoane triphosphatase, as well as glycogen levels were studied. Carcinomas differed from adenomas in having elevated enzyme activity significantly more often than adenomas. However, the carcinomas showed elevated glycogen levels less frequently than adenomas. Histochemically, pulmonary metastases resembled the primary hepatocellular carcinomas from which they were derived. Tumors of dieldrin animals were notable in having increased activity of all the enzymes which we studied more frequently than tumors of diethylnitrosamine animals or of controls. Differences in enzyme activity between the three mouse strains were slight.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalCarcinogenesis
Volume3
Issue number8
DOIs
StatePublished - 1982

Fingerprint

Enzyme activity
Mouse
Enzymes
Tumors
Adenoma
Dieldrin
Phosphatases
Diethylnitrosamine
Tumor
Neoplasms
Liver
Glycogen
Animals
Carcinoma
Glucose-6-Phosphatase
Succinate Dehydrogenase
Glucose
Metastasis
Alkaline Phosphatase
Hepatocellular Carcinoma

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

Enzyme histochemical characteristics of spontaneous and induced hepatocellular neoplasms in mice. / Ruebner, Boris H.; Gershwin, M. Eric; Meierhenry, Earl F.; Dunn, Pat.

In: Carcinogenesis, Vol. 3, No. 8, 1982, p. 899-903.

Research output: Contribution to journalArticle

Ruebner, Boris H. ; Gershwin, M. Eric ; Meierhenry, Earl F. ; Dunn, Pat. / Enzyme histochemical characteristics of spontaneous and induced hepatocellular neoplasms in mice. In: Carcinogenesis. 1982 ; Vol. 3, No. 8. pp. 899-903.
@article{f9c1e6f3372049ee9c319e9b9183d8b7,
title = "Enzyme histochemical characteristics of spontaneous and induced hepatocellular neoplasms in mice",
abstract = "Hepatocellular neoplasms are known to differ in enzyme activity from the surrounding non-neoplastic liver. We have compared histochemically the enzyme activity of spontaneous hepatocellular tumors in mice with tumors induced by diethylnitrosamine and dieldrin. Some neoplasms had increased activity, others had decreased enzyme activity, yet others had the same activity as the surrounding liver. Alkaline phosphatase, glucose-6-phosphatase, succinic dehydrogenase and adenoane triphosphatase, as well as glycogen levels were studied. Carcinomas differed from adenomas in having elevated enzyme activity significantly more often than adenomas. However, the carcinomas showed elevated glycogen levels less frequently than adenomas. Histochemically, pulmonary metastases resembled the primary hepatocellular carcinomas from which they were derived. Tumors of dieldrin animals were notable in having increased activity of all the enzymes which we studied more frequently than tumors of diethylnitrosamine animals or of controls. Differences in enzyme activity between the three mouse strains were slight.",
author = "Ruebner, {Boris H.} and Gershwin, {M. Eric} and Meierhenry, {Earl F.} and Pat Dunn",
year = "1982",
doi = "10.1093/carcin/3.8.899",
language = "English (US)",
volume = "3",
pages = "899--903",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Enzyme histochemical characteristics of spontaneous and induced hepatocellular neoplasms in mice

AU - Ruebner, Boris H.

AU - Gershwin, M. Eric

AU - Meierhenry, Earl F.

AU - Dunn, Pat

PY - 1982

Y1 - 1982

N2 - Hepatocellular neoplasms are known to differ in enzyme activity from the surrounding non-neoplastic liver. We have compared histochemically the enzyme activity of spontaneous hepatocellular tumors in mice with tumors induced by diethylnitrosamine and dieldrin. Some neoplasms had increased activity, others had decreased enzyme activity, yet others had the same activity as the surrounding liver. Alkaline phosphatase, glucose-6-phosphatase, succinic dehydrogenase and adenoane triphosphatase, as well as glycogen levels were studied. Carcinomas differed from adenomas in having elevated enzyme activity significantly more often than adenomas. However, the carcinomas showed elevated glycogen levels less frequently than adenomas. Histochemically, pulmonary metastases resembled the primary hepatocellular carcinomas from which they were derived. Tumors of dieldrin animals were notable in having increased activity of all the enzymes which we studied more frequently than tumors of diethylnitrosamine animals or of controls. Differences in enzyme activity between the three mouse strains were slight.

AB - Hepatocellular neoplasms are known to differ in enzyme activity from the surrounding non-neoplastic liver. We have compared histochemically the enzyme activity of spontaneous hepatocellular tumors in mice with tumors induced by diethylnitrosamine and dieldrin. Some neoplasms had increased activity, others had decreased enzyme activity, yet others had the same activity as the surrounding liver. Alkaline phosphatase, glucose-6-phosphatase, succinic dehydrogenase and adenoane triphosphatase, as well as glycogen levels were studied. Carcinomas differed from adenomas in having elevated enzyme activity significantly more often than adenomas. However, the carcinomas showed elevated glycogen levels less frequently than adenomas. Histochemically, pulmonary metastases resembled the primary hepatocellular carcinomas from which they were derived. Tumors of dieldrin animals were notable in having increased activity of all the enzymes which we studied more frequently than tumors of diethylnitrosamine animals or of controls. Differences in enzyme activity between the three mouse strains were slight.

UR - http://www.scopus.com/inward/record.url?scp=0020316719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020316719&partnerID=8YFLogxK

U2 - 10.1093/carcin/3.8.899

DO - 10.1093/carcin/3.8.899

M3 - Article

VL - 3

SP - 899

EP - 903

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 8

ER -