Enzyme evolution: Generation of a bifunctional enzyme by fusion of adjacent genes

Joseph Yourno; Tadahiko Kohno; John R. Roth

doi:10.1038/228820a0

Enzyme evolution: Generation of a bifunctional enzyme by fusion of adjacent genes

Joseph Yourno, Tadahiko Kohno, John R. Roth

Microbiology

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Two genes encoding distinct enzymes have been functionally fused by mutation. After fusion, the two genes act as one and produce a single polypeptide chain responsible for both catalytic activities.

Original language	English (US)
Pages (from-to)	820-824
Number of pages	5
Journal	Nature
Volume	228
Issue number	5274
DOIs	https://doi.org/10.1038/228820a0
State	Published - 1970

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title = "Enzyme evolution: Generation of a bifunctional enzyme by fusion of adjacent genes",

abstract = "Two genes encoding distinct enzymes have been functionally fused by mutation. After fusion, the two genes act as one and produce a single polypeptide chain responsible for both catalytic activities.",

author = "Joseph Yourno and Tadahiko Kohno and Roth, {John R.}",

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Enzyme evolution: Generation of a bifunctional enzyme by fusion of adjacent genes

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