Enzyme evolution: Generation of a bifunctional enzyme by fusion of adjacent genes

Joseph Yourno, Tadahiko Kohno, John R. Roth

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Two genes encoding distinct enzymes have been functionally fused by mutation. After fusion, the two genes act as one and produce a single polypeptide chain responsible for both catalytic activities.

Original languageEnglish (US)
Pages (from-to)820-824
Number of pages5
JournalNature
Volume228
Issue number5274
DOIs
StatePublished - 1970

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Gene Fusion
Enzymes
Genes
Peptides
Mutation

ASJC Scopus subject areas

  • General

Cite this

Enzyme evolution : Generation of a bifunctional enzyme by fusion of adjacent genes. / Yourno, Joseph; Kohno, Tadahiko; Roth, John R.

In: Nature, Vol. 228, No. 5274, 1970, p. 820-824.

Research output: Contribution to journalArticle

Yourno, Joseph ; Kohno, Tadahiko ; Roth, John R. / Enzyme evolution : Generation of a bifunctional enzyme by fusion of adjacent genes. In: Nature. 1970 ; Vol. 228, No. 5274. pp. 820-824.
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