Enzymatic synthesis of fluorinated mechanistic probes for sialidases and sialyltransferases

Harshal A. Chokhawala, Hongzhi Cao, Hai Yu, Xi Chen

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

A general, convenient, and efficient enzymatic approach for producing fluorinated mechanistic probes for sialidases and sialyltransferases is described. Other than the reported sialyltransferase inhibitor CMP-3F(axial)Neu5Ac, CMP-3F(equatorial)Sia derivatives (in which Sia is Neu5Ac or Neu5Gc) have been synthesized along with CMP-3F(axial)Neu5Gc and CMP-3F(axial)KDN as novel inhibitors and important mechanistic probes for sialyltransferases. 3-Fluoro-sialosides have been enzymatically synthesized and could be used as potential inhibitors and mechanistic probes for sialidases and as probes for sialic acid-binding proteins.

Original languageEnglish (US)
Pages (from-to)10630-10631
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number35
DOIs
StatePublished - Sep 5 2007

ASJC Scopus subject areas

  • Chemistry(all)

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