Environmentally relevant concentrations of bifenthrin affect the expression of estrogen and glucocorticoid receptors in brains of female western mosquitofish

Isaac Y. Ligocki, Amelia Munson, Victoria Farrar, Rechelle Viernes, Andrew Sih, Richard E Connon, Rebecca M. Calisi

Research output: Contribution to journalArticle

Abstract

In recent decades, pyrethroid pesticides have been deemed a safer alternative to previously used pesticides. While some evidence supports this assumption in mammals and birds, exposure to certain pyrethroids can affect concentrations of hormones vital to reproduction in fish. Thus, we hypothesized that pyrethroid exposure impacts fish reproductive behavior and the expression of genes associated with reproduction. We tested our hypothesis by examining effects of the widely used pyrethroid pesticide, bifenthrin, on the reproductive behaviors of the broadly distributed livebearing western mosquitofish, Gambusia affinis. We exposed sexually mature female fish to one of five environmentally relevant concentrations of bifenthrin and conducted behavioral assays to assess reproductive, social, and space use behaviors before and after exposure. We did not detect changes in behaviors measured in response to bifenthrin. However, exposure was associated with increased expression of an estrogen receptor gene (ER-α) and glucocorticoid receptor (GR) in brain tissue at bifenthrin concentrations at concentrations of 5.90 and 24.82 ng/L, and 5.90 and 12.21 ng/L, respectively. Our study supports the perspective that the use of multiple endpoints through integrative approaches is essential for understanding the cumulative impact of pollutants. Integrating physiological, morphological, and behavioral investigations of nonlethal concentrations of pollutants like bifenthrin may heighten our potential to predict their impact on individuals, populations, and communities.

Original languageEnglish (US)
Pages (from-to)121-131
Number of pages11
JournalAquatic Toxicology
DOIs
StatePublished - Apr 1 2019

Fingerprint

bifenthrin
Gambusia affinis
Glucocorticoid Receptors
Pyrethrins
Estrogen Receptors
brain
pyrethrins
Pesticides
Brain
Reproductive Behavior
Fishes
pesticides
pyrethroid
reproductive behavior
Reproduction
fish
pollutants
Cyprinodontiformes
space use
fish behavior

Keywords

  • Endocrine disruption
  • Estrogen receptor
  • Fish neurobiology
  • Gambusia
  • Glucocorticoid receptor
  • Pyrethroid
  • Reproduction
  • Stress

ASJC Scopus subject areas

  • Aquatic Science
  • Health, Toxicology and Mutagenesis

Cite this

Environmentally relevant concentrations of bifenthrin affect the expression of estrogen and glucocorticoid receptors in brains of female western mosquitofish. / Ligocki, Isaac Y.; Munson, Amelia; Farrar, Victoria; Viernes, Rechelle; Sih, Andrew; Connon, Richard E; Calisi, Rebecca M.

In: Aquatic Toxicology, 01.04.2019, p. 121-131.

Research output: Contribution to journalArticle

Ligocki, Isaac Y. ; Munson, Amelia ; Farrar, Victoria ; Viernes, Rechelle ; Sih, Andrew ; Connon, Richard E ; Calisi, Rebecca M. / Environmentally relevant concentrations of bifenthrin affect the expression of estrogen and glucocorticoid receptors in brains of female western mosquitofish. In: Aquatic Toxicology. 2019 ; pp. 121-131.
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