Abstract
This chapter reviews the interaction of various environmental factors with the aging lung. In general, environmental factors enhance aging effects which, in turn, lead to clinical disease in susceptible subjects. The lung has a remarkable array of responses and defenses to oxidative stress. Age-related changes in antioxidant defenses include decreased lung tissue ascorbic acid and reduction of glutathione. A progressive reduction in antioxidant defenses might contribute to the decline of FEV and increased risk for emphysema with increasing age. Some particulates, such as cigarette smoke, coal dust and silica, have intrinsic free radical activity. Others, such as diesel emissions, contain compounds that catalyze the generation of reactive oxygen species (ROS) and most exogenous toxins activate lung resident cells to produce ROS. Many of these agents have been associated with accelerated decline in.
| Original language | English (US) |
|---|---|
| Title of host publication | The Lung: Development, Aging and The Environment |
| Publisher | Elsevier Inc. |
| Pages | 378-395 |
| Number of pages | 18 |
| ISBN (Print) | 9780080481357, 9780123247513 |
| DOIs | |
| State | Published - Dec 3 2003 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Environmental Determinants of Lung Aging. / Green, Francis H Y; Pinkerton, Kent E.
The Lung: Development, Aging and The Environment. Elsevier Inc., 2003. p. 378-395.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Environmental Determinants of Lung Aging
AU - Green, Francis H Y
AU - Pinkerton, Kent E
PY - 2003/12/3
Y1 - 2003/12/3
N2 - This chapter reviews the interaction of various environmental factors with the aging lung. In general, environmental factors enhance aging effects which, in turn, lead to clinical disease in susceptible subjects. The lung has a remarkable array of responses and defenses to oxidative stress. Age-related changes in antioxidant defenses include decreased lung tissue ascorbic acid and reduction of glutathione. A progressive reduction in antioxidant defenses might contribute to the decline of FEV and increased risk for emphysema with increasing age. Some particulates, such as cigarette smoke, coal dust and silica, have intrinsic free radical activity. Others, such as diesel emissions, contain compounds that catalyze the generation of reactive oxygen species (ROS) and most exogenous toxins activate lung resident cells to produce ROS. Many of these agents have been associated with accelerated decline in.
AB - This chapter reviews the interaction of various environmental factors with the aging lung. In general, environmental factors enhance aging effects which, in turn, lead to clinical disease in susceptible subjects. The lung has a remarkable array of responses and defenses to oxidative stress. Age-related changes in antioxidant defenses include decreased lung tissue ascorbic acid and reduction of glutathione. A progressive reduction in antioxidant defenses might contribute to the decline of FEV and increased risk for emphysema with increasing age. Some particulates, such as cigarette smoke, coal dust and silica, have intrinsic free radical activity. Others, such as diesel emissions, contain compounds that catalyze the generation of reactive oxygen species (ROS) and most exogenous toxins activate lung resident cells to produce ROS. Many of these agents have been associated with accelerated decline in.
UR - http://www.scopus.com/inward/record.url?scp=84872414169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872414169&partnerID=8YFLogxK
U2 - 10.1016/B978-012324751-3/50062-0
DO - 10.1016/B978-012324751-3/50062-0
M3 - Chapter
AN - SCOPUS:84872414169
SN - 9780080481357
SN - 9780123247513
SP - 378
EP - 395
BT - The Lung: Development, Aging and The Environment
PB - Elsevier Inc.
ER -