Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment

E. J. Mufson, E. Y. Chen, E. J. Cochran, Laurel A Beckett, D. A. Bennett, J. H. Kordower

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

The deposition of β-amyloid within the entorhinal cortex (EC) may play a key role in the development of mild cognitive impairment (MCI) in the elderly. To examine the relationship of β-amyloid deposition to MCI, EC tissue immunostained for this protein was quantitated from a cohort of aged Catholic religious clergy with a clinical diagnosis of MCI and compared to those with no cognitive impairment (NCI) and Alzheimer's disease (AD). β- amyloid staining was seen in 12 of the 20 NCI, in 10 of 12 MCI, and in all 12 AD cases within the EC. β-amyloid immunoreactivity displayed two patterns within the EC: (1) a crescent-shaped band within layers 3-4 or (2) bilaminar staining mainly within layers 2-3 and 5-6. Ten cases failed to display any detectable β-amyloid immunoreactivity. Despite the heterogeneity of β- amyloid loads within the clinical groups, decomposing an analysis of variance revealed a significant difference across groups in mean β-amyloid load within the EC based upon a linear trend analysis. Multiple comparisons testing revealed that NCI individuals had a significantly lower mean β- amyloid load (1.32) than AD individuals (4.55). The MCI individuals had a mean intermediate (2.60) load between NCI and AD, but not statistically distinguishable from the mean for either NCI or AD. Spearman rank correlation showed a trend for decreasing MMSE with increasing amyloid load that failed to reach statistical significance. Since many NCI cases displayed β-amyloid loads equal to or greater than that seen in some MCI and some AD cases, it is mostly likely that deposition of this protein is not the sole pathogenic event underlying cognitive impairment in the elderly.

Original languageEnglish (US)
Pages (from-to)469-490
Number of pages22
JournalExperimental Neurology
Volume158
Issue number2
DOIs
StatePublished - Aug 1999
Externally publishedYes

Fingerprint

Entorhinal Cortex
Amyloid
Alzheimer Disease
Cognitive Dysfunction
Clergy
Staining and Labeling
Analysis of Variance
Proteins

Keywords

  • Aging
  • Amyloid
  • Cortex
  • Dementia
  • Histochemistry
  • Plaques
  • Tangles

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Mufson, E. J., Chen, E. Y., Cochran, E. J., Beckett, L. A., Bennett, D. A., & Kordower, J. H. (1999). Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment. Experimental Neurology, 158(2), 469-490. https://doi.org/10.1006/exnr.1999.7086

Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment. / Mufson, E. J.; Chen, E. Y.; Cochran, E. J.; Beckett, Laurel A; Bennett, D. A.; Kordower, J. H.

In: Experimental Neurology, Vol. 158, No. 2, 08.1999, p. 469-490.

Research output: Contribution to journalArticle

Mufson, EJ, Chen, EY, Cochran, EJ, Beckett, LA, Bennett, DA & Kordower, JH 1999, 'Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment', Experimental Neurology, vol. 158, no. 2, pp. 469-490. https://doi.org/10.1006/exnr.1999.7086
Mufson, E. J. ; Chen, E. Y. ; Cochran, E. J. ; Beckett, Laurel A ; Bennett, D. A. ; Kordower, J. H. / Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment. In: Experimental Neurology. 1999 ; Vol. 158, No. 2. pp. 469-490.
@article{30de694a838041d38c998dff8c75941c,
title = "Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment",
abstract = "The deposition of β-amyloid within the entorhinal cortex (EC) may play a key role in the development of mild cognitive impairment (MCI) in the elderly. To examine the relationship of β-amyloid deposition to MCI, EC tissue immunostained for this protein was quantitated from a cohort of aged Catholic religious clergy with a clinical diagnosis of MCI and compared to those with no cognitive impairment (NCI) and Alzheimer's disease (AD). β- amyloid staining was seen in 12 of the 20 NCI, in 10 of 12 MCI, and in all 12 AD cases within the EC. β-amyloid immunoreactivity displayed two patterns within the EC: (1) a crescent-shaped band within layers 3-4 or (2) bilaminar staining mainly within layers 2-3 and 5-6. Ten cases failed to display any detectable β-amyloid immunoreactivity. Despite the heterogeneity of β- amyloid loads within the clinical groups, decomposing an analysis of variance revealed a significant difference across groups in mean β-amyloid load within the EC based upon a linear trend analysis. Multiple comparisons testing revealed that NCI individuals had a significantly lower mean β- amyloid load (1.32) than AD individuals (4.55). The MCI individuals had a mean intermediate (2.60) load between NCI and AD, but not statistically distinguishable from the mean for either NCI or AD. Spearman rank correlation showed a trend for decreasing MMSE with increasing amyloid load that failed to reach statistical significance. Since many NCI cases displayed β-amyloid loads equal to or greater than that seen in some MCI and some AD cases, it is mostly likely that deposition of this protein is not the sole pathogenic event underlying cognitive impairment in the elderly.",
keywords = "Aging, Amyloid, Cortex, Dementia, Histochemistry, Plaques, Tangles",
author = "Mufson, {E. J.} and Chen, {E. Y.} and Cochran, {E. J.} and Beckett, {Laurel A} and Bennett, {D. A.} and Kordower, {J. H.}",
year = "1999",
month = "8",
doi = "10.1006/exnr.1999.7086",
language = "English (US)",
volume = "158",
pages = "469--490",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Entorhinal cortex β-amyloid load in individuals with mild cognitive impairment

AU - Mufson, E. J.

AU - Chen, E. Y.

AU - Cochran, E. J.

AU - Beckett, Laurel A

AU - Bennett, D. A.

AU - Kordower, J. H.

PY - 1999/8

Y1 - 1999/8

N2 - The deposition of β-amyloid within the entorhinal cortex (EC) may play a key role in the development of mild cognitive impairment (MCI) in the elderly. To examine the relationship of β-amyloid deposition to MCI, EC tissue immunostained for this protein was quantitated from a cohort of aged Catholic religious clergy with a clinical diagnosis of MCI and compared to those with no cognitive impairment (NCI) and Alzheimer's disease (AD). β- amyloid staining was seen in 12 of the 20 NCI, in 10 of 12 MCI, and in all 12 AD cases within the EC. β-amyloid immunoreactivity displayed two patterns within the EC: (1) a crescent-shaped band within layers 3-4 or (2) bilaminar staining mainly within layers 2-3 and 5-6. Ten cases failed to display any detectable β-amyloid immunoreactivity. Despite the heterogeneity of β- amyloid loads within the clinical groups, decomposing an analysis of variance revealed a significant difference across groups in mean β-amyloid load within the EC based upon a linear trend analysis. Multiple comparisons testing revealed that NCI individuals had a significantly lower mean β- amyloid load (1.32) than AD individuals (4.55). The MCI individuals had a mean intermediate (2.60) load between NCI and AD, but not statistically distinguishable from the mean for either NCI or AD. Spearman rank correlation showed a trend for decreasing MMSE with increasing amyloid load that failed to reach statistical significance. Since many NCI cases displayed β-amyloid loads equal to or greater than that seen in some MCI and some AD cases, it is mostly likely that deposition of this protein is not the sole pathogenic event underlying cognitive impairment in the elderly.

AB - The deposition of β-amyloid within the entorhinal cortex (EC) may play a key role in the development of mild cognitive impairment (MCI) in the elderly. To examine the relationship of β-amyloid deposition to MCI, EC tissue immunostained for this protein was quantitated from a cohort of aged Catholic religious clergy with a clinical diagnosis of MCI and compared to those with no cognitive impairment (NCI) and Alzheimer's disease (AD). β- amyloid staining was seen in 12 of the 20 NCI, in 10 of 12 MCI, and in all 12 AD cases within the EC. β-amyloid immunoreactivity displayed two patterns within the EC: (1) a crescent-shaped band within layers 3-4 or (2) bilaminar staining mainly within layers 2-3 and 5-6. Ten cases failed to display any detectable β-amyloid immunoreactivity. Despite the heterogeneity of β- amyloid loads within the clinical groups, decomposing an analysis of variance revealed a significant difference across groups in mean β-amyloid load within the EC based upon a linear trend analysis. Multiple comparisons testing revealed that NCI individuals had a significantly lower mean β- amyloid load (1.32) than AD individuals (4.55). The MCI individuals had a mean intermediate (2.60) load between NCI and AD, but not statistically distinguishable from the mean for either NCI or AD. Spearman rank correlation showed a trend for decreasing MMSE with increasing amyloid load that failed to reach statistical significance. Since many NCI cases displayed β-amyloid loads equal to or greater than that seen in some MCI and some AD cases, it is mostly likely that deposition of this protein is not the sole pathogenic event underlying cognitive impairment in the elderly.

KW - Aging

KW - Amyloid

KW - Cortex

KW - Dementia

KW - Histochemistry

KW - Plaques

KW - Tangles

UR - http://www.scopus.com/inward/record.url?scp=0032864612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032864612&partnerID=8YFLogxK

U2 - 10.1006/exnr.1999.7086

DO - 10.1006/exnr.1999.7086

M3 - Article

C2 - 10415154

AN - SCOPUS:0032864612

VL - 158

SP - 469

EP - 490

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 2

ER -