Abstract
The strain and entropy effects of the lactone formation from ω- bromoalkane-carboxylate ions in ring sizes 3 to 23 is reevaluated. We find that ΔH((+)) is the largest contributor to the observed rates ΔG((+)) for ring sizes 3 to 6, while-T ΔS((+)) has little influence, -TΔS((+)) has more effect on the observed rates for ring sizes 8 and larger.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 193-199 |
| Number of pages | 7 |
| Journal | Bioorganic Chemistry |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 30 1998 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
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Cite this
Lightstone, F. C., & Bruice, T. C. (1998). Enthalpy and entropy in ring closure reactions. Bioorganic Chemistry, 26(4), 193-199. https://doi.org/10.1006/bioo.1998.1096