Enthalpy and entropy in ring closure reactions

Felice C Lightstone, Thomas C. Bruice

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

The strain and entropy effects of the lactone formation from ω- bromoalkane-carboxylate ions in ring sizes 3 to 23 is reevaluated. We find that ΔH((+)) is the largest contributor to the observed rates ΔG((+)) for ring sizes 3 to 6, while-T ΔS((+)) has little influence, -TΔS((+)) has more effect on the observed rates for ring sizes 8 and larger.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalBioorganic Chemistry
Volume26
Issue number4
DOIs
StatePublished - Oct 30 1998

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Entropy
Lactones
Enthalpy
Ions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Enthalpy and entropy in ring closure reactions. / Lightstone, Felice C; Bruice, Thomas C.

In: Bioorganic Chemistry, Vol. 26, No. 4, 30.10.1998, p. 193-199.

Research output: Contribution to journal › Article

Lightstone, FC & Bruice, TC 1998, 'Enthalpy and entropy in ring closure reactions', Bioorganic Chemistry, vol. 26, no. 4, pp. 193-199. https://doi.org/10.1006/bioo.1998.1096
Lightstone FC, Bruice TC. Enthalpy and entropy in ring closure reactions. Bioorganic Chemistry. 1998 Oct 30;26(4):193-199. https://doi.org/10.1006/bioo.1998.1096
Lightstone, Felice C ; Bruice, Thomas C. / Enthalpy and entropy in ring closure reactions. In: Bioorganic Chemistry. 1998 ; Vol. 26, No. 4. pp. 193-199.
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