Abstract
The strain and entropy effects of the lactone formation from ω- bromoalkane-carboxylate ions in ring sizes 3 to 23 is reevaluated. We find that ΔH((+)) is the largest contributor to the observed rates ΔG((+)) for ring sizes 3 to 6, while-T ΔS((+)) has little influence, -TΔS((+)) has more effect on the observed rates for ring sizes 8 and larger.
Original language | English (US) |
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Pages (from-to) | 193-199 |
Number of pages | 7 |
Journal | Bioorganic Chemistry |
Volume | 26 |
Issue number | 4 |
DOIs | |
State | Published - Oct 30 1998 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery