Enthalpy and entropy in ring closure reactions

Felice C Lightstone, Thomas C. Bruice

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The strain and entropy effects of the lactone formation from ω- bromoalkane-carboxylate ions in ring sizes 3 to 23 is reevaluated. We find that ΔH((+)) is the largest contributor to the observed rates ΔG((+)) for ring sizes 3 to 6, while-T ΔS((+)) has little influence, -TΔS((+)) has more effect on the observed rates for ring sizes 8 and larger.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalBioorganic Chemistry
Volume26
Issue number4
DOIs
StatePublished - Oct 30 1998

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

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