Enterokinase

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Enterokinase is a glycoprotein and is now designated enteropeptidase (E.C.3.4.4.8.). It is present in the duodenal and jejunal mucosa. Pancreatic proteolytic enzymes are secreted as proenzymes. Enterokinase converts trypsinogen to trypsin in the duodenal lumen. Duodenopancreatic reflux of duodenal enterokinase may be important in the pathogenesis of experimental and clinical acute pancreatitis. Congenital enterokinase deficiency is a distinct clinical entity characterized by diarrhea, failure to thrive, hypoproteinemia, and edema. Acquired enterokinase deficiency may occur in some diffuse small bowel diseases. Steatorrhea of celiac sprue may be due partly to the fact that deficiency of secretin and cholecystokinin may interfere with the action of enterokinase. The interrelationship between secretin, cholecystokinin, enterokinase, and bile salts is not completely understood.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume206
Issue number2
StatePublished - 1994
Externally publishedYes

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Enteropeptidase
Secretin
Cholecystokinin
Duodenogastric Reflux
Trypsinogen
Hypoproteinemia
Steatorrhea
Failure to Thrive
Enzyme Precursors
Celiac Disease
Bile Acids and Salts
Pancreatitis
Trypsin
Diarrhea
Edema
Glycoproteins
Mucous Membrane
Peptide Hydrolases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Enterokinase. / Mann, Nirmal S; Mann, Surinder K.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 206, No. 2, 1994, p. 114-118.

Research output: Contribution to journalArticle

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