Enterohepatic circulation of cobalamin in the nonhuman primate

Ralph Green, Donald W. Jacobsen, Susan V. Van Tonder, Michael C. Kew, Jack Metz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Biliary excretion of cobalamin was studied in baboons after intravenous injection of 57Co-radio-labeled cyanocobalamin. Radioactivity appeared in bile after 20 min, and up to 4.4% of the dose was recovered in 6 h. It was estimated that 4 μg cobalamin traverses the baboon biliary tract each day. These studies in the nonhuman primate confirm that there is considerable biliary excretion of cobalamin and that enterohepatic circulation of the vitamin is important for maintenance of normal cobalamin balance.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalGastroenterology
Volume81
Issue number4
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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