Enterococcus infections in foals

A. T. Willis, K G Magdesian, Barbara A Byrne, J. M. Edman

Research output: Contribution to journalArticle

Abstract

Enterococci have been increasing in prevalence in foal sepsis over the past three decades. There are no published studies in the peer-reviewed literature documenting common sites of infection, antimicrobial susceptibility, or outcome specifically associated with enterococcal infections in foals. Our objectives were to evaluate the sites of origin, antimicrobial susceptibility, and survival outcome to discharge in foals with enterococcal infections compared with foals with sepsis of another bacterial etiology. Seventy-five foals 0–30 days of age with cultures positive for Enterococcus and 170 control foals 0–30 days of age with cultures positive for other bacteria were included. Enterococcus was 2.67 times (95% confidence interval [CI], 1.49–4.80; P = 0.0012) more likely to be isolated from the lower urogenital tract of foals than were other bacteria. Enterococci were less likely to be isolated from blood cultures than other bacteria, with an odds ratio (OR) of 0.17 (95% CI 0.09−0.35; P < 0.0001). For Enterococcus isolates, 48% (n = 29/61) had a multiple antimicrobial resistance (MAR) index of ≥30% and 46% (n = 28/61) had a multiple drug resistance (MDR) index of ≥30%. Foals with enterococcal infections were less likely to survive to discharge (49.9% vs. 63.5%; P = 0.03). Enterococcus is commonly isolated from the lower urogenital tract of foals, is often multidrug resistant, and foals with enterococcal infections were less likely to survive. Multidrug resistance is common among enterococcal isolates, and therefore antimicrobial susceptibility testing of cultured isolates is warranted.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalVeterinary Journal
Volume248
DOIs
StatePublished - Jun 1 2019

Fingerprint

Enterococcus
foals
Infection
infection
Multiple Drug Resistance
Bacteria
Sepsis
sepsis (infection)
Confidence Intervals
anti-infective agents
multiple drug resistance
confidence interval
bacteria
Odds Ratio
peers
antibiotic resistance
odds ratio
etiology
blood

Keywords

  • Enterococci
  • Faecium
  • Foal
  • Multidrug resistant
  • Urogenital

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Enterococcus infections in foals. / Willis, A. T.; Magdesian, K G; Byrne, Barbara A; Edman, J. M.

In: Veterinary Journal, Vol. 248, 01.06.2019, p. 42-47.

Research output: Contribution to journalArticle

Willis, A. T. ; Magdesian, K G ; Byrne, Barbara A ; Edman, J. M. / Enterococcus infections in foals. In: Veterinary Journal. 2019 ; Vol. 248. pp. 42-47.
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