Enteric defensins are essential regulators of intestinal microbial ecology

Nita H. Salzman, Kuiechun Hung, Dipica Haribhai, Hiutung Chu, Jenny Karlsson-Sjöberg, Elad Amir, Paul Teggatz, Melissa Barman, Michael Hayward, Daniel Eastwood, Maaike Stoel, Yanjiao Zhou, Erica Sodergren, George M. Weinstock, Charles L Bevins, Calvin B. Williams, Nicolaas A. Bos

Research output: Contribution to journalArticle

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Abstract

Antimicrobial peptides are important effectors of innate immunity throughout the plant and animal kingdoms. In the mammalian small intestine, Paneth cell α-defensins are antimicrobial peptides that contribute to host defense against enteric pathogens. To determine if α-defensins also govern intestinal microbial ecology, we analyzed the intestinal microbiota of mice expressing a human α-defensin gene (DEFA5) and in mice lacking an enzyme required for the processing of mouse α-defensins. In these complementary models, we detected significant α-defensin-dependent changes in microbiota composition, but not in total bacterial numbers. Furthermore, DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17)-producing lamina propria T cells. Our data ascribe a new homeostatic role to α-defensins in regulating the makeup of the commensal microbiota.

Original languageEnglish (US)
Pages (from-to)76-83
Number of pages8
JournalNature Immunology
Volume11
Issue number1
DOIs
StatePublished - Jan 2010

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ASJC Scopus subject areas

  • Immunology

Cite this

Salzman, N. H., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E., Teggatz, P., Barman, M., Hayward, M., Eastwood, D., Stoel, M., Zhou, Y., Sodergren, E., Weinstock, G. M., Bevins, C. L., Williams, C. B., & Bos, N. A. (2010). Enteric defensins are essential regulators of intestinal microbial ecology. Nature Immunology, 11(1), 76-83. https://doi.org/10.1038/ni.1825