Enteric defensins are essential regulators of intestinal microbial ecology

Nita H. Salzman, Kuiechun Hung, Dipica Haribhai, Hiutung Chu, Jenny Karlsson-Sjöberg, Elad Amir, Paul Teggatz, Melissa Barman, Michael Hayward, Daniel Eastwood, Maaike Stoel, Yanjiao Zhou, Erica Sodergren, George M. Weinstock, Charles L Bevins, Calvin B. Williams, Nicolaas A. Bos

Research output: Contribution to journalArticle

671 Citations (Scopus)

Abstract

Antimicrobial peptides are important effectors of innate immunity throughout the plant and animal kingdoms. In the mammalian small intestine, Paneth cell α-defensins are antimicrobial peptides that contribute to host defense against enteric pathogens. To determine if α-defensins also govern intestinal microbial ecology, we analyzed the intestinal microbiota of mice expressing a human α-defensin gene (DEFA5) and in mice lacking an enzyme required for the processing of mouse α-defensins. In these complementary models, we detected significant α-defensin-dependent changes in microbiota composition, but not in total bacterial numbers. Furthermore, DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17)-producing lamina propria T cells. Our data ascribe a new homeostatic role to α-defensins in regulating the makeup of the commensal microbiota.

Original languageEnglish (US)
Pages (from-to)76-83
Number of pages8
JournalNature Immunology
Volume11
Issue number1
DOIs
StatePublished - Jan 2010

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Defensins
Ecology
Microbiota
Paneth Cells
Peptides
Interleukin-17
Innate Immunity
Small Intestine
Mucous Membrane
Bacteria
T-Lymphocytes
Enzymes
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Salzman, N. H., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E., ... Bos, N. A. (2010). Enteric defensins are essential regulators of intestinal microbial ecology. Nature Immunology, 11(1), 76-83. https://doi.org/10.1038/ni.1825

Enteric defensins are essential regulators of intestinal microbial ecology. / Salzman, Nita H.; Hung, Kuiechun; Haribhai, Dipica; Chu, Hiutung; Karlsson-Sjöberg, Jenny; Amir, Elad; Teggatz, Paul; Barman, Melissa; Hayward, Michael; Eastwood, Daniel; Stoel, Maaike; Zhou, Yanjiao; Sodergren, Erica; Weinstock, George M.; Bevins, Charles L; Williams, Calvin B.; Bos, Nicolaas A.

In: Nature Immunology, Vol. 11, No. 1, 01.2010, p. 76-83.

Research output: Contribution to journalArticle

Salzman, NH, Hung, K, Haribhai, D, Chu, H, Karlsson-Sjöberg, J, Amir, E, Teggatz, P, Barman, M, Hayward, M, Eastwood, D, Stoel, M, Zhou, Y, Sodergren, E, Weinstock, GM, Bevins, CL, Williams, CB & Bos, NA 2010, 'Enteric defensins are essential regulators of intestinal microbial ecology', Nature Immunology, vol. 11, no. 1, pp. 76-83. https://doi.org/10.1038/ni.1825
Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjöberg J, Amir E et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nature Immunology. 2010 Jan;11(1):76-83. https://doi.org/10.1038/ni.1825
Salzman, Nita H. ; Hung, Kuiechun ; Haribhai, Dipica ; Chu, Hiutung ; Karlsson-Sjöberg, Jenny ; Amir, Elad ; Teggatz, Paul ; Barman, Melissa ; Hayward, Michael ; Eastwood, Daniel ; Stoel, Maaike ; Zhou, Yanjiao ; Sodergren, Erica ; Weinstock, George M. ; Bevins, Charles L ; Williams, Calvin B. ; Bos, Nicolaas A. / Enteric defensins are essential regulators of intestinal microbial ecology. In: Nature Immunology. 2010 ; Vol. 11, No. 1. pp. 76-83.
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