Enhancing the barrier properties of colloidosomes using silica nanoparticle aggregates

Yuan Zhao, Nily Dan, Yuanjie Pan, Nitin Nitin, Rohan V. Tikekar

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Recent interest is focused on microcapsules stabilized using colloidal nanoparticles - termed 'colloidosomes - for encapsulation applications in food, drug and cosmetic industries. However, due to electrostatic repulsion between similarly charged particles, shells composed of single-type nanoparticles tend to be monolayer-thick and relatively permeable. We investigated a self-assembly method for controlling the permeability of colloidal shells using aggregates composed of oppositely charged silica nanoparticles. Using a combination of rapid fluorescence based method and theoretical diffusion models, we found that colloidosomes whose shells contained colloidal silica aggregates displayed lower permeability to peroxyl radicals than ones stabilized by single type of silica nanoparticles. Furthermore, the permeability varied as a function of the ratio of oppositely charged silica nanoparticles in the shell. The ability to control the permeability of colloidosomes, while using a simple self-assembly synthesis method, will enable enhanced control over release kinetics and oxidative stability of encapsulants.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalJournal of Food Engineering
Issue number4
StatePublished - 2013


  • Colloidosome
  • Diffusion
  • Encapsulation
  • Interfacial permeability

ASJC Scopus subject areas

  • Food Science


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