Enhancers

Kuang-Yu Jen

doi:10.1016/B978-0-12-374984-0.00477-0

Enhancers

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Enhancers are regulatory DNA sequences of gene expression that augment the activity of a promoter in an orientation-, position-, and distance-independent manner. These sequences play a key role in the regulation of tissue-specific gene expression in higher eukaryotes. Classically, trans-acting gene regulatory proteins are thought to bind to enhancers in order to impact transcriptional activity of their associated promoters. However, more recently, evidence has emerged that points to other diverse mechanisms by which enhancers may exert their effects on gene expression, including through epigenetic modifications, alterations of chromatin structure, and noncoding RNAs.

Original language	English (US)
Title of host publication	Brenner's Encyclopedia of Genetics
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	493-494
Number of pages	2
ISBN (Electronic)	9780080961569
ISBN (Print)	9780123749840
DOIs	https://doi.org/10.1016/B978-0-12-374984-0.00477-0
State	Published - Feb 27 2013
Externally published	Yes

Keywords

Activator
DNA looping
Gene expression
Promoter
Transcription factor

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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AU - Jen, Kuang-Yu

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AB - Enhancers are regulatory DNA sequences of gene expression that augment the activity of a promoter in an orientation-, position-, and distance-independent manner. These sequences play a key role in the regulation of tissue-specific gene expression in higher eukaryotes. Classically, trans-acting gene regulatory proteins are thought to bind to enhancers in order to impact transcriptional activity of their associated promoters. However, more recently, evidence has emerged that points to other diverse mechanisms by which enhancers may exert their effects on gene expression, including through epigenetic modifications, alterations of chromatin structure, and noncoding RNAs.

KW - Activator

KW - DNA looping

KW - Gene expression

KW - Promoter

KW - Transcription factor

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DO - 10.1016/B978-0-12-374984-0.00477-0

M3 - Chapter

AN - SCOPUS:85043236781

SN - 9780123749840

SP - 493

EP - 494

BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -

Enhancers

Abstract

Keywords

ASJC Scopus subject areas

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