Enhancement of primary and secondary immune responses by interferon-gamma.

Tilahun Yilma, S. Owens, E. H. Fennie, K. P. Anderson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We have investigated the effects of interferon-gamma (IFN-gamma) administered with "G" glycoprotein of vesicular stomatitis virus (VSV), on the neutralizing antibody response. Treatment of mice or cattle with recombinant DNA-derived IFN-gamma at the time of primary immunization with "G" glycoprotein enhanced the secondary virus-neutralizing antibody response that followed a booster administration of the same antigen without IFN-gamma treatment. Enhancement was statistically significant, and occurred at relatively low doses of IFN-gamma in the absence of any additional adjuvants. Cattle treated with IFN-gamma at the time of primary immunization were also more resistant to VSV challenge than those immunized without IFN-gamma treatment. Such treatment in conjunction with primary immunization may therefore provide a practical means of enhancing protection from viral challenge without inflammatory adjuvants or boosters.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume251
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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