Enhanced safety and efficacy of live attenuated SIV vaccines by prevaccination with recombinant vaccines

Leslie Jones, Shabbir Ahmad, Kenneth Chan, Paulo Verardi, William R. Morton, Richard Grant, Tilahun Yilma

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The only vaccines shown to be protective against intravenous challenge with virulent virus in the simian immunodeficiency virus (SIV)/macaque model are attenuated live SIVs. However, these vaccines have several disadvantages: 1) they persist indefinitely in vaccinated macaques; 2) they are pathogenic to neonatal macaques; and 3) they are lethal in some adult macaques. To enhance the safety and efficacy of these vaccines, we immunized macaques first with recombinant vaccines and then inoculated the animals with SIV (Δnef). In the first experiment, preimmunized macaques advanced to disease slower than controls after challenge with virulent SIV; five animals survived for 3 years without disease and only the vaccine virus (SIV(Δnef)) could be isolated at this time. In the second experiment, preimmunized animals had lower virus loads and no disease compared to controls. (C) Munksgaard, Copenhagen.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalJournal of Medical Primatology
Volume29
Issue number3-4
StatePublished - 2000

Keywords

  • Attenuation
  • Live vaccines
  • Load
  • Macaques
  • Subunit
  • Virus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Jones, L., Ahmad, S., Chan, K., Verardi, P., Morton, W. R., Grant, R., & Yilma, T. (2000). Enhanced safety and efficacy of live attenuated SIV vaccines by prevaccination with recombinant vaccines. Journal of Medical Primatology, 29(3-4), 231-239.