Enhanced patency of venous dacron grafts by endothelial cell sodding

Zhong Gao Wang, Guangdi Li, Jidong Wu, Wei Du, Lee Li-Qun Pu, Hai Zhang, Dajie Wang, Bauer E. Sumpio

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The effect of microvessel endothelial cell (EC) sodding on the patency of Dacron grafts interposed in canine inferior vena cava was studied. EC were harvested enzymatically from canine omentum and isolated by density gradient centrifugation. Preclotted, knitted Dacron grafts were sodded with >106 EC/cm2 surface. The results demonstrate significant improvement in patency of sodded grafts placed in the inferior vena cava as compared with control grafts (p<0.001 in grafts with a distal arteriovenous fistula and p<0.05 in grafts without a distal fistula). The neointima of the sodded grafts were thinner and scanning electron microscopy confirmed the presence of a confluent layer of EC. In addition, the production of prostacyclin but not thromboxane A2 was significantly enhanced in the sodded grafts as compared with controls. We conclude that microvessel EC sodding of Dacron grafts significantly improves the patency rate and inhibits neointimal thickening of the prosthesis. The mechanism is unknown but may involve a more rapid endothelialization of the graft surface with the potential of producing more prostacyclin and less thromboxane A2.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalAnnals of Vascular Surgery
Volume7
Issue number5
DOIs
StatePublished - Sep 1993
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Wang, Z. G., Li, G., Wu, J., Du, W., Pu, L. L-Q., Zhang, H., Wang, D., & Sumpio, B. E. (1993). Enhanced patency of venous dacron grafts by endothelial cell sodding. Annals of Vascular Surgery, 7(5), 429-436. https://doi.org/10.1007/BF02002126