Enhanced non-invasive respiratory sampling from bottlenose dolphins for breath metabolomics measurements

Konstantin O. Zamuruyev, Alexander A. Aksenov, Mark Baird, Alberto Pasamontes, Celeste Parry, Soraya Foutouhi, Stephanie Venn-Watson, Bart C Weimer, Jean Pierre Delplanque, Cristina E Davis

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chemical analysis of exhaled breath metabolites is an emerging alternative to traditional clinical testing for many physiological conditions. The main advantage of breath analysis is its inherent non-invasive nature and ease of sample collection. Therefore, there exists a great interest in further development of this method for both humans and animals. The physiology of cetaceans is exceptionally well suited for breath analysis due to their explosive breathing behavior and respiratory tract morphology. At the present time, breath analysis in cetaceans has very limited practical applications, in large part due to lack of widely adopted sampling device(s) and methodologies that are well-standardized. Here, we present an optimized design and the operating principles of a portable apparatus for reproducible collection of exhaled breath condensate from small cetaceans, such as bottlenose dolphins (Tursiops truncatus). The device design is optimized to meet two criteria: standardized collection and preservation of information-rich metabolomic content of the biological sample, and animal comfort and ease of breath sample collection. The intent is to furnish a fully-benchmarked technology that can be widely adopted by researchers and conservationists to spur further developments of breath analysis applications for marine mammal health assessments.

Original languageEnglish (US)
Article number046005
JournalJournal of Breath Research
Volume10
Issue number4
DOIs
StatePublished - Sep 30 2016

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Bottle-Nosed Dolphin
Metabolomics
Equipment Design
Respiratory System
Mammals
Respiration
Research Personnel
Technology
Equipment and Supplies
Health

Keywords

  • bottlenose dolphins (Tursiops truncatus)
  • breath analysis
  • breath sampling
  • cetaceans
  • exhaled breath condensate (EBC)
  • volatile organic compounds (VOCs)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Enhanced non-invasive respiratory sampling from bottlenose dolphins for breath metabolomics measurements. / Zamuruyev, Konstantin O.; Aksenov, Alexander A.; Baird, Mark; Pasamontes, Alberto; Parry, Celeste; Foutouhi, Soraya; Venn-Watson, Stephanie; Weimer, Bart C; Delplanque, Jean Pierre; Davis, Cristina E.

In: Journal of Breath Research, Vol. 10, No. 4, 046005, 30.09.2016.

Research output: Contribution to journalArticle

Zamuruyev, KO, Aksenov, AA, Baird, M, Pasamontes, A, Parry, C, Foutouhi, S, Venn-Watson, S, Weimer, BC, Delplanque, JP & Davis, CE 2016, 'Enhanced non-invasive respiratory sampling from bottlenose dolphins for breath metabolomics measurements', Journal of Breath Research, vol. 10, no. 4, 046005. https://doi.org/10.1088/1752-7155/10/4/046005
Zamuruyev, Konstantin O. ; Aksenov, Alexander A. ; Baird, Mark ; Pasamontes, Alberto ; Parry, Celeste ; Foutouhi, Soraya ; Venn-Watson, Stephanie ; Weimer, Bart C ; Delplanque, Jean Pierre ; Davis, Cristina E. / Enhanced non-invasive respiratory sampling from bottlenose dolphins for breath metabolomics measurements. In: Journal of Breath Research. 2016 ; Vol. 10, No. 4.
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