Enhanced manual and oral motor reaction time in young adult female fragile X premutation carriers

Naomi J. Goodrich-Hunsaker, Ling M. Wong, Yingratana McLennan, Flora Tassone, Danielle J Harvey, Susan M. Rivera, Tony J Simon

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A previous study reported preliminary results of enhanced processing of simple visual information in the form of faster reaction times, in female fragile X premutation carriers (fXPCs). In this study, we assessed manual and oral motor reaction times in 30 female fXPCs and 20 neurotypical (NT) controls. Participants completed two versions of the reaction time task; one version required a manual motor response and the other version required an oral motor response. Results revealed that the female fXPCs displayed faster reaction times for both manual and oral motor responses relative to NT controls. Molecular measures including CGG repeat length, FMR1 mRNA levels, and age were not associated with performance in either group. Given previously reported age and CGG repeat modulated performance on a magnitude comparison task in this same group of premutation carriers, results from the current study seem to suggest that female fXPCs may have spared basic psychomotor functionality.

Original languageEnglish (US)
Pages (from-to)746-750
Number of pages5
JournalJournal of the International Neuropsychological Society
Issue number4
StatePublished - Jul 2011


  • Anxiety
  • Corticopontine tract
  • Cortiospinal tract
  • Motor cortex
  • Psychomotor performance
  • X-linked genetic disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)


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