Enhanced lung toxicity of intratracheally instilled cadmium chloride in selenium-deficient rats

Krishna A. Reddy, Stanley T. Omaye, Glenn K. Hasegawa, Carroll E Cross

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In order to further characterize biochemical correlates of CdCl2-induced lung injury, CdCl2 lung toxicity was studied in Se-deficient rats. A solution of 0.5 μmol/kg of CdCl2 was intratracheally instilled into chronic respiratory disease-free 70-day-old rats fed a basal Se-deficient diet or a basal diet supplemented with 0.5 or 2.0 ppm of Se for 40 days. Within 3 days Se-deficient rats showed signs of marked respiratory distress and 25% had died, whereas rats from Se-supplemented groups all survived this time period. As evidenced by gross examination and lung water contents, Se-deficient rats exhibited a greater degree of inflammatory pulmonary edema than did rats from Se-supplemented groups. The results of the various enzymatic and biochemical determinations may be interpreted as being consistent with greater damage occurring in the Se-deficient rats.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalToxicology and Applied Pharmacology
Volume43
Issue number2
DOIs
StatePublished - 1978

Fingerprint

Cadmium Chloride
Selenium
Toxicity
Rats
Lung
Nutrition
Diet
Pulmonary diseases
Lung Injury
Pulmonary Edema
Water content
Chronic Disease
Water

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Enhanced lung toxicity of intratracheally instilled cadmium chloride in selenium-deficient rats. / Reddy, Krishna A.; Omaye, Stanley T.; Hasegawa, Glenn K.; Cross, Carroll E.

In: Toxicology and Applied Pharmacology, Vol. 43, No. 2, 1978, p. 249-257.

Research output: Contribution to journalArticle

Reddy, Krishna A. ; Omaye, Stanley T. ; Hasegawa, Glenn K. ; Cross, Carroll E. / Enhanced lung toxicity of intratracheally instilled cadmium chloride in selenium-deficient rats. In: Toxicology and Applied Pharmacology. 1978 ; Vol. 43, No. 2. pp. 249-257.
@article{6aa6f86f18734f40948f1b880d10b360,
title = "Enhanced lung toxicity of intratracheally instilled cadmium chloride in selenium-deficient rats",
abstract = "In order to further characterize biochemical correlates of CdCl2-induced lung injury, CdCl2 lung toxicity was studied in Se-deficient rats. A solution of 0.5 μmol/kg of CdCl2 was intratracheally instilled into chronic respiratory disease-free 70-day-old rats fed a basal Se-deficient diet or a basal diet supplemented with 0.5 or 2.0 ppm of Se for 40 days. Within 3 days Se-deficient rats showed signs of marked respiratory distress and 25{\%} had died, whereas rats from Se-supplemented groups all survived this time period. As evidenced by gross examination and lung water contents, Se-deficient rats exhibited a greater degree of inflammatory pulmonary edema than did rats from Se-supplemented groups. The results of the various enzymatic and biochemical determinations may be interpreted as being consistent with greater damage occurring in the Se-deficient rats.",
author = "Reddy, {Krishna A.} and Omaye, {Stanley T.} and Hasegawa, {Glenn K.} and Cross, {Carroll E}",
year = "1978",
doi = "10.1016/0041-008X(78)90004-2",
language = "English (US)",
volume = "43",
pages = "249--257",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Enhanced lung toxicity of intratracheally instilled cadmium chloride in selenium-deficient rats

AU - Reddy, Krishna A.

AU - Omaye, Stanley T.

AU - Hasegawa, Glenn K.

AU - Cross, Carroll E

PY - 1978

Y1 - 1978

N2 - In order to further characterize biochemical correlates of CdCl2-induced lung injury, CdCl2 lung toxicity was studied in Se-deficient rats. A solution of 0.5 μmol/kg of CdCl2 was intratracheally instilled into chronic respiratory disease-free 70-day-old rats fed a basal Se-deficient diet or a basal diet supplemented with 0.5 or 2.0 ppm of Se for 40 days. Within 3 days Se-deficient rats showed signs of marked respiratory distress and 25% had died, whereas rats from Se-supplemented groups all survived this time period. As evidenced by gross examination and lung water contents, Se-deficient rats exhibited a greater degree of inflammatory pulmonary edema than did rats from Se-supplemented groups. The results of the various enzymatic and biochemical determinations may be interpreted as being consistent with greater damage occurring in the Se-deficient rats.

AB - In order to further characterize biochemical correlates of CdCl2-induced lung injury, CdCl2 lung toxicity was studied in Se-deficient rats. A solution of 0.5 μmol/kg of CdCl2 was intratracheally instilled into chronic respiratory disease-free 70-day-old rats fed a basal Se-deficient diet or a basal diet supplemented with 0.5 or 2.0 ppm of Se for 40 days. Within 3 days Se-deficient rats showed signs of marked respiratory distress and 25% had died, whereas rats from Se-supplemented groups all survived this time period. As evidenced by gross examination and lung water contents, Se-deficient rats exhibited a greater degree of inflammatory pulmonary edema than did rats from Se-supplemented groups. The results of the various enzymatic and biochemical determinations may be interpreted as being consistent with greater damage occurring in the Se-deficient rats.

UR - http://www.scopus.com/inward/record.url?scp=0017802841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017802841&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(78)90004-2

DO - 10.1016/0041-008X(78)90004-2

M3 - Article

C2 - 635914

AN - SCOPUS:0017802841

VL - 43

SP - 249

EP - 257

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -