Enhanced inflammatory responses in α-tocopherol transfer protein null mice

Bettina C. Schock, Albert Van Der Vliet, Ana M. Corbacho, Scott W. Leonard, Erik Finkelstein, Giuseppe Valacchi, Ute Obermueller-Jevic, Carroll E Cross, Maret G. Traber

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The liver preferentially secretes α-tocopherol into plasma under the control of the hepatic α-tocopherol transfer protein (α-TTP). α-TTP-null mice (Ttpa-/- mice) are vitamin E deficient, therefore were used for investigations of in vivo responses to sub-normal tissue α-tocopherol concentrations during inflammation. Increased basal oxidative stress in Ttpa-/- mice was documented by increased plasma lipid peroxidation, and superoxide production by bone marrow-derived neutrophils stimulated in vitro with phorbol 12-myristate 13-acetate. Lipopolysaccharide (LPS) injected intraperitoneally induced increases in lung and liver HO-1 and iNOS, as well as plasma NOx in Ttpa+/+ mice. LPS induced more modest increases in these markers in Ttpa-/- mice, while more marked increases in plasma IL-10 and lung lavage TNFα were observed. Taken together, these results demonstrate that α-tocopherol is important for proper modulation of inflammatory responses and that sub-optimal α-tocopherol concentrations may derange inflammatory-immune responses.

Original languageEnglish (US)
Pages (from-to)162-169
Number of pages8
JournalArchives of Biochemistry and Biophysics
Issue number1
StatePublished - Mar 1 2004


  • α-Tocopherol
  • α-TTP
  • Heme oxygenase-1
  • Immune response
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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