Enhanced asynchronous Ca2+ oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion

Zhengyu Cao, Susan Hulsizer, Yanjun Cui, Dalyir L. Pretto, Kyung Ho Kim, Paul J Hagerman, Flora Tassone, Isaac N Pessah

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background: FMR1 CGG expansion repeats in the premutation range have not been linked to astrocyte pathophysiology. Results: Premutation cortical astrocytes display decreased Glu transporter expression/activity and enhanced asynchronous Ca2+ oscillations. Conclusion: Glu transport and Ca 2+ signaling defects in premutation astrocytes could contribute to FXTAS neuropathology. Significance: Premutation astrocytes may have an etiological role in FXTAS neuropathology.

Original languageEnglish (US)
Pages (from-to)13831-13841
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number19
DOIs
StatePublished - May 10 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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