Enhanced adrenergic excitation of serotonergic dorsal raphe neurons in genetically obese rats

Patricia Ohliger-Frerking, John M. Horowitz, Barbara A Horwitz

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Serotonergic neurons in the dorsal raphe nucleus (DRN) project to the ventromedial hypothalamus (VMH), where serotonin (5-HT) release modulates feeding. 5-HT release in the VMH is altered in genetically obese vs. lean Zucker rats. Serotonergic DRN neurons are subject to adrenergic and serotonergic neuromodulation. To determine if the difference in 5-HT release between lean and obese rats might be due to differences in these neuromodulatory pathways, we examined the effects of phenylephrine (PE) and 5-HT on serotonergic DRN neurons using current-clamp recording. Cells from lean and obese animals responded similarly to 5-HT, but cells from obese rats exhibited both a larger depolarization and increased firing rate in response to PE than did cells from lean rats. This indicates that DRN neurons of obese rats have an enhanced adrenergic drive.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalNeuroscience Letters
Volume332
Issue number2
DOIs
StatePublished - Oct 31 2002
Externally publishedYes

Keywords

  • Obesity
  • Phenylephrine
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

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