Engineering Vascularized Organoid-on-a-Chip Models

Venktesh S. Shirure, Christopher C.W. Hughes, Steven C. George

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Recreating human organ-level function in vitro is a rapidly evolving field that integrates tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids. A critical component of all organs is the vasculature. Herein, we discuss general strategies to create vascularized organoids, including common source materials, and survey previous work using vascularized organoids to recreate specific organ functions and simulate tumor progression. Vascularization is not only an essential component of individual organ function but also responsible for coupling the fate of all organs and their functions. While some success in coupling two or more organs together on a single platform has been demonstrated, we argue that the future of vascularized organoid technology lies in creating organoid systems complete with tissue-specific microvasculature and in coupling multiple organs through a dynamic vascular network to create systems that can respond to changing physiological conditions.

Original languageEnglish (US)
Pages (from-to)141-167
Number of pages27
JournalAnnual Review of Biomedical Engineering
StatePublished - Jul 13 2021


  • angiogenesis
  • microphysiological systems
  • organ-on-a-chip
  • self-assembled vasculature
  • tumor-on-a-chip
  • Vasculogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering


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